Skip to main content

Advertisement

SpringerLink
Log in

Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Nasal Cavity, Paranasal Sinuses and Skull Base

  • Original Paper
  • Published:
Head and Neck Pathology Aims and scope Submit manuscript

Abstract

The sinonasal tract remains an epicenter of a diverse array of neoplasia. This paper discusses changes to the WHO classification system of tumors involving this area. In particular, seromucinous hamartoma, NUT carcinoma, biphenotypic sinonasal sarcoma, HPV-related carcinoma with adenoid cystic features, SMARCB1-deficient carcinoma, and renal cell-like adenocarcinoma are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Lewis JS Jr. Sinonasal squamous cell carcinoma: a review with emphasis on emerging histologic subtypes and the role of human papillomavirus. Head Neck Pathol. 2016;10:60–7.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Bishop JA, Guo TW, Smith DF, Wang H, Ogawa T, Pai SI, Westra WH. Human papillomavirus-related carcinomas of the sinonasal tract. Am J Surg Pathol. 2013;37:185–92.

    Article  PubMed  PubMed Central  Google Scholar 

  3. El-Mofty SK, Lu DW. Prevalence of high-risk human papillomavirus DNA in nonkeratinizing (cylindrical cell) carcinoma of the sinonasal tract: a distinct clinicopathologic and molecular disease entity. Am J Surg Pathol. 2005;29:1367–72.

    Article  PubMed  Google Scholar 

  4. Larque AB, Hakim S, Ordi J, Nadal A, Diaz A, del Pino M, Marimon L, Alobid I, Cardesa A, Alos L. High-risk human papillomavirus is transcriptionally active in a subset of sinonasal squamous cell carcinomas. Mod Pathol. 2014;27:343–51.

    CAS  PubMed  Google Scholar 

  5. Jo VY, Mills SE, Stoler MH, Stelow EB. Papillary squamous cell carcinoma of the head and neck: frequent association with human papillomavirus infection and invasive carcinoma. Am J Surg Pathol. 2009;33:1720–4.

    Article  PubMed  Google Scholar 

  6. Rytkonen AE, Hirvikoski PP, Salo TA. Lymphoepithelial carcinoma: two case reports and a systematic review of oral and sinonasal cases. Head Neck Pathol. 2011;5:327–34.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Barnes L. Intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. Am J Surg Pathol. 1986;10:192–202.

    Article  CAS  PubMed  Google Scholar 

  8. Batsakis JG, Mackay B, Ordonez NG. Enteric-type adenocarcinoma of the nasal cavity. An electron microscopic and immunocytochemical study. Cancer. 1984;54:855–60.

    Article  CAS  PubMed  Google Scholar 

  9. Cathro HP, Mills SE. Immunophenotypic differences between intestinal-type and low-grade papillary sinonasal adenocarcinomas: an immunohistochemical study of 22 cases utilizing CDX2 and MUC2. Am J Surg Pathol. 2004;28:1026–32.

    Article  PubMed  Google Scholar 

  10. Acheson ED, Cowdell RH, Hadfield E, Macbeth RG. Nasal cancer in woodworkers in the furniture industry. Br Med J. 1968;2:587–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Hadfield EH. A study of adenocarcinoma of the paranasal sinuses in woodworkers in the furniture industry. Ann R Coll Surg Engl. 1970;46:301–19.

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Hadfield EH, Macbeth RG. Adenocarcinoma of ethmoids in furniture workers. Ann Otol Rhinol Laryngol. 1971;80:699–703.

    Article  CAS  PubMed  Google Scholar 

  13. Heffner DK, Hyams VJ, Hauck KW, Lingeman C. Low-grade adenocarcinoma of the nasal cavity and paranasal sinuses. Cancer. 1982;50:312–22.

    Article  CAS  PubMed  Google Scholar 

  14. Jo VY, Mills SE, Cathro HP, Carlson DL, Stelow EB. Low-grade sinonasal adenocarcinomas: the association with and distinction from respiratory epithelial adenomatoid hamartomas and other glandular lesions. Am J Surg Pathol. 2009;33:401–8.

    Article  PubMed  Google Scholar 

  15. Kleinsasser O. Terminal tubulus adenocarcinoma of the nasal seromucous glands. A specific entity. Arch Otorhinolaryngol. 1985;241:183–93.

    Article  CAS  PubMed  Google Scholar 

  16. Stelow EB, Mills SE, Jo VY, Carlson DL. Adenocarcinoma of the upper aerodigestive tract. Adv Anat Pathol. 2010;17:262–9.

    Article  PubMed  Google Scholar 

  17. Stelow EB, Jo VY, Mills SE, Carlson DL: A histologic and immunohistochemical stduy of high-grade non-intestinal sinonasal adenocarcinomas. Am J Surg Pathol 2011;35:971–80 In Press.

    Article  Google Scholar 

  18. Perez-Ordonez B, Caruana SM, Huvos AG, Shah JP. Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses. Hum Pathol. 1998;29:826–32.

    Article  CAS  PubMed  Google Scholar 

  19. Weinreb I, Perez-Ordonez B. Non-small cell neuroendocrine carcinoma of the sinonasal tract and nasopharynx. Report of 2 cases and review of the literature. Head Neck Pathol. 2007;1:21–6.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Franchi A, Rocchetta D, Palomba A, Degli Innocenti DR, Castiglione F, Spinelli G. Primary combined neuroendocrine and squamous cell carcinoma of the maxillary sinus: report of a case with immunohistochemical and molecular characterization. Head Neck Pathol. 2015;9:107–13.

    Article  PubMed  Google Scholar 

  21. Thompson ED, Stelow EB, Mills SE, Westra WH, Bishop JA. Large cell neuroendocrine carcinoma of the head and neck: a clinicopathologic series of 10 cases with an emphasis on HPV status. Am J Surg Pathol. 2016;40:471–8.

    Article  PubMed  Google Scholar 

  22. Wang CP, Hsieh CY, Chang YL, Lou PJ, Yang TL, Ting LL, Ko JY. Postirradiated neuroendocrine carcinoma of the sinonasal tract. Laryngoscope. 2008;118:804–9.

    Article  PubMed  Google Scholar 

  23. Frierson HF Jr, Mills SE, Fechner RE, Taxy JB, Levine PA. Sinonasal undifferentiated carcinoma. An aggressive neoplasm derived from schneiderian epithelium and distinct from olfactory neuroblastoma. Am J Surg Pathol. 1986;10:771–9.

    Article  PubMed  Google Scholar 

  24. Heffner DK, Hyams VJ. Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses: a clinicopathologic study of 20 cases. Cancer. 1984;53:2140–54.

    Article  CAS  PubMed  Google Scholar 

  25. Salem F, Rosenblum MK, Jhanwar SC, Kancherla P, Ghossein RA, Carlson DL. Teratocarcinosarcoma of the nasal cavity and paranasal sinuses: report of 3 cases with assessment for chromosome 12p status. Hum Pathol. 2008;39:605–9.

    Article  CAS  PubMed  Google Scholar 

  26. Kumar S, Perlman E, Pack S, Davis M, Zhang H, Meltzer P, Tsokos M. Absence of EWS/FLI1 fusion in olfactory neuroblastomas indicates these tumors do not belong to the Ewing’s sarcoma family. Hum Pathol. 1999;30:1356–60.

    Article  CAS  PubMed  Google Scholar 

  27. Taxy JB, Bharani NK, Mills SE, Frierson HF Jr, Gould VE. The spectrum of olfactory neural tumors. A light-microscopic immunohistochemical and ultrastructural analysis. Am J Surg Pathol. 1986;10:687–95.

    Article  CAS  PubMed  Google Scholar 

  28. Bishop JA, Alaggio R, Zhang L, Seethala RR, Antonescu CR. Adamantinoma-like Ewing family tumors of the head and neck: a pitfall in the differential diagnosis of basaloid and myoepithelial carcinomas. Am J Surg Pathol. 2015;39:1267–74.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Crane GM, Duffield AS. Hematolymphoid lesions of the sinonasal tract. Semin Diagn Pathol. 2016;33:71–80.

    Article  PubMed  Google Scholar 

  30. Kreisel FH. Hematolymphoid lesions of the sinonasal tract. Head and Neck Pathol. 2016;10:109–17.

    Article  Google Scholar 

  31. Thompson LD, Miettinen M, Wenig BM. Sinonasal-type hemangiopericytoma: a clinicopathologic and immunophenotypic analysis of 104 cases showing perivascular myoid differentiation. Am J Surg Pathol. 2003;27:737–49.

    Article  PubMed  Google Scholar 

  32. Lasota J, Felisiak-Golabek A, Aly FZ, Wang ZF, Thompson LD, Miettinen M. Nuclear expression and gain-of-function beta-catenin mutation in glomangiopericytoma (sinonasal-type hemangiopericytoma): insight into pathogenesis and a diagnostic marker. Mod Pathol. 2015;28:715–20.

    Article  CAS  PubMed  Google Scholar 

  33. Weinreb I, Gnepp DR, Laver NM, Hoschar AP, Hunt JL, Seethala RR, Barnes EL, Chetty R, Perez-Ordonez B. Seromucinous hamartomas: a clinicopathological study of a sinonasal glandular lesion lacking myoepithelial cells. Histopathology. 2009;54:205–13.

    Article  PubMed  Google Scholar 

  34. Ozolek JA, Barnes EL, Hunt JL. Basal/myoepithelial cells in chronic sinusitis, respiratory epithelial adenomatoid hamartoma, inverted papilloma, and intestinal-type and nonintestinal-type sinonasal adenocarcinoma: an immunohistochemical study. Arch Pathol Lab Med. 2007;131:530–7.

    CAS  PubMed  Google Scholar 

  35. Jo VY, Mills SE, Cathro HP, Carlson DL, Stelow EB. Low-grade sinonasal adenocarcinomas: the association with and distinction from respiratory epithelial adenomatoid hamartomas and other glandular lesions. Am J Surg Pathol 2008; 33:401–408

    Google Scholar 

  36. Ambrosini-Spaltro A, Morandi L, Spagnolo DV, Cavazza A, Brisigotti M, Damiani S, Jain S, Eusebi V. Nasal seromucinous hamartoma (microglandular adenosis of the nose): a morphological and molecular study of five cases. Virchows Arch. 2010;457:727–34.

    Article  PubMed  Google Scholar 

  37. Kees UR, Mulcahy MT, Willoughby ML. Intrathoracic carcinoma in an 11-year-old girl showing a translocation t(15;19). Am J Pediatric Hematol. 1991;13:459–64.

    Article  CAS  Google Scholar 

  38. Kubonishi I, Takehara N, Iwata J, Sonobe H, Ohtsuki Y, Abe T, Miyoshi I. Novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma. Cancer Res. 1991;51:3327–8.

    CAS  PubMed  Google Scholar 

  39. French C. NUT midline carcinoma. Nature reviews Cancer. 2014;14:149–50.

    Article  CAS  PubMed  Google Scholar 

  40. French CA. The importance of diagnosing NUT midline carcinoma. Head Neck Pathol. 2013;7:11–6.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Stelow EB. A review of NUT midline carcinoma. Head Neck Pathol. 2011;5:31–5.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Bauer DE, Mitchell CM, Strait KM, Lathan CS, Stelow EB, Luer SC, Muhammed S, Evans AG, Sholl LM, Rosai J, Giraldi E, Oakley RP, Rodriguez-Galindo C, London WB, Sallan SE, Bradner JE, French CA. Clinicopathologic features and long-term outcomes of NUT midline carcinoma. Clin Cancer Res. 2012;18:5773–9.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Stelow EB, Bellizzi AM, Taneja K, Mills SE, Legallo RD, Kutok JL, Aster JC, French CA. NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract. Am J Surg Pathol. 2008;32:828–34.

    Article  PubMed  Google Scholar 

  44. Solomon LW, Magliocca KR, Cohen C, Muller S. Retrospective analysis of nuclear protein in testis (NUT) midline carcinoma in the upper aerodigestive tract and mediastinum. Oral Surg Oral Med Oral Pathol Oral Radiol 2014;119:213–220

    Google Scholar 

  45. Bishop JA, Westra WH. NUT midline carcinomas of the sinonasal tract. Am J Surg Pathol. 2012;36:1216–21.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Fang W, French CA, Cameron MJ, Han Y, Liu H. Clinicopathological significance of NUT rearrangements in poorly differentiated malignant tumors of the upper respiratory tract. Int J Surg Pathol. 2013;21:102–10.

    Article  CAS  PubMed  Google Scholar 

  47. Bishop JA, French CA, Ali SZ. Cytopathologic features of NUT midline carcinoma: A series of 26 specimens from 13 patients. Cancer Cytopathol. 2016;124:901–908

    Article  Google Scholar 

  48. Bellizzi AM, Bruzzi C, French CA, Stelow EB. The cytologic features of NUT midline carcinoma. Cancer. 2009;117:508–15.

    PubMed  Google Scholar 

  49. French CA, Ramirez CL, Kolmakova J, Hickman TT, Cameron MJ, Thyne ME, Kutok JL, Toretsky JA, Tadavarthy AK, Kees UR, Fletcher JA, Aster JC. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene. 2008;27:2237–42.

    Article  CAS  PubMed  Google Scholar 

  50. Haack H, Johnson LA, Fry CJ, Crosby K, Polakiewicz RD, Stelow EB, Hong SM, Schwartz BE, Cameron MJ, Rubin MA, Chang MC, Aster JC, French CA. Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody. Am J Surg Pathol. 2009;33:984–91.

    Article  PubMed  PubMed Central  Google Scholar 

  51. French CA. Pathogenesis of NUT midline carcinoma. Annu Rev Pathol. 2012;7:247–65.

    Article  CAS  PubMed  Google Scholar 

  52. Lewis JT, Oliveira AM, Nascimento AG, Schembri-Wismayer D, Moore EA, Olsen KD, Garcia JG, Lonzo ML, Lewis JE. Low-grade sinonasal sarcoma with neural and myogenic features: a clinicopathologic analysis of 28 cases. Am J Surg Pathol. 2012;36:517–25.

    Article  PubMed  Google Scholar 

  53. Huang SC, Ghossein RA, Bishop JA, Zhang L, Chen TC, Huang HY, Antonescu CR. Novel PAX3-NCOA1 fusions in biphenotypic sinonasal sarcoma with focal rhabdomyoblastic differentiation. Am J Surg Pathol. 2016;40:51–9.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Wang X, Bledsoe KL, Graham RP, Asmann YW, Viswanatha DS, Lewis JE, Lewis JT, Chou MM, Yaszemski MJ, Jen J, Westendorf JJ, Oliveira AM. Recurrent PAX3-MAML3 fusion in biphenotypic sinonasal sarcoma. Nat Genet. 2014;46:666–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Powers KA, Han LM, Chiu AG, Aly FZ. Low-grade sinonasal sarcoma with neural and myogenic features-diagnostic challenge and pathogenic insight. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119:e265–e9.

    Article  PubMed  Google Scholar 

  56. Rooper LM, Huang SC, Antonescu CR, Westra WH, Bishop JA. Biphenotypic sinonasal sarcoma: an expanded immunoprofile including consistent nuclear beta-catenin positivity and absence of SOX10 expression. Hum Pathol. 2016;55:44–50.

    Article  PubMed  Google Scholar 

  57. Wong WJ, Lauria A, Hornick JL, Xiao S, Fletcher JA, Marino-Enriquez A. Alternate PAX3-FOXO1 oncogenic fusion in biphenotypic sinonasal sarcoma. Genes Chromosomes Cancer. 2016;55:25–9.

    Article  CAS  PubMed  Google Scholar 

  58. Ukpo OC, Flanagan JJ, Ma XJ, Luo Y, Thorstad WL, Lewis JS Jr. High-risk human papillomavirus E6/E7 mRNA detection by a novel in situ hybridization assay strongly correlates with p16 expression and patient outcomes in oropharyngeal squamous cell carcinoma. Am J Surg Pathol. 2011;35:1343–50.

    Article  PubMed  Google Scholar 

  59. Singhi AD, Westra WH. Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience. Cancer. 2010;116:2166–73.

    PubMed  Google Scholar 

  60. Bishop JA, Ma XJ, Wang H, Luo Y, Illei PB, Begum S, Taube JM, Koch WM, Westra WH. Detection of transcriptionally active high-risk HPV in patients with head and neck squamous cell carcinoma as visualized by a novel E6/E7 mRNA in situ hybridization method. Am J Surg Pathol. 2012;36:1874–82.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Poling JS, Ma XJ, Bui S, Luo Y, Li R, Koch WM, Westra WH. Human papillomavirus (HPV) status of non-tobacco related squamous cell carcinomas of the lateral tongue. Oral Oncol. 2014;50:306–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Lewis JS Jr, Ukpo OC, Ma XJ, Flanagan JJ, Luo Y, Thorstad WL, Chernock RD. Transcriptionally-active high-risk human papillomavirus is rare in oral cavity and laryngeal/hypopharyngeal squamous cell carcinomas–a tissue microarray study utilizing E6/E7 mRNA in situ hybridization. Histopathology. 2012;60:982–91.

    Article  PubMed  Google Scholar 

  63. Alos L, Moyano S, Nadal A, Alobid I, Blanch JL, Ayala E, Lloveras B, Quint W, Cardesa A, Ordi J. Human papillomaviruses are identified in a subgroup of sinonasal squamous cell carcinomas with favorable outcome. Cancer. 2009;115:2701–9.

    Article  PubMed  Google Scholar 

  64. Bishop JA, Ogawa T, Stelow EB, Moskaluk CA, Koch WM, Pai SI, Westra WH. Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract. Am J Surg Pathol. 2013;37:836–44.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Hwang SJ, Ok S, Lee HM, Lee E, Park IH. Human papillomavirus-related carcinoma with adenoid cystic-like features of the inferior turbinate: a case report. Auris Nasus Larynx. 2015;42:53–5.

    Article  PubMed  Google Scholar 

  66. Biegel JA, Kalpana G, Knudsen ES, Packer RJ, Roberts CW, Thiele CJ, Weissman B, Smith M. The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors. Cancer Res. 2002;62:323–8.

    CAS  PubMed  Google Scholar 

  67. Biegel JA, Zhou JY, Rorke LB, Stenstrom C, Wainwright LM, Fogelgren B. Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors. Cancer Res. 1999;59:74–9.

    CAS  PubMed  Google Scholar 

  68. Rorke LB, Packer RJ, Biegel JA. Central nervous system atypical teratoid/rhabdoid tumors of infancy and childhood: definition of an entity. J Neurosurg. 1996;85:56–65.

    Article  CAS  PubMed  Google Scholar 

  69. Biegel JA, Burk CD, Parmiter AH, Emanuel BS. Molecular analysis of a partial deletion of 22q in a central nervous system rhabdoid tumor. Genes Chromosomes Cancer. 1992;5:104–8.

    Article  CAS  PubMed  Google Scholar 

  70. Biegel JA, Rorke LB, Emanuel BS. Monosomy 22 in rhabdoid or atypical teratoid tumors of the brain. N Engl J Med. 1989;321:906.

    CAS  PubMed  Google Scholar 

  71. Shashi V, Lovell MA, von Kap-herr C, Waldron P, Golden WL. Malignant rhabdoid tumor of the kidney: involvement of chromosome 22. Genes Chromosomes Cancer. 1994;10:49–54.

    Article  CAS  PubMed  Google Scholar 

  72. Schofield DE, Beckwith JB, Sklar J. Loss of heterozygosity at chromosome regions 22q11-12 and 11p15.5 in renal rhabdoid tumors. Genes Chromosomes Cancer. 1996;15:10–7.

    Article  CAS  PubMed  Google Scholar 

  73. Hornick JL, Dal Cin P, Fletcher CD. Loss of INI1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma. Am J Surg Pathol. 2009;33:542–50.

    Article  PubMed  Google Scholar 

  74. Modena P, Lualdi E, Facchinetti F, Galli L, Teixeira MR, Pilotti S, Sozzi G. SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas. Cancer Res. 2005;65:4012–9.

    Article  CAS  PubMed  Google Scholar 

  75. Le Loarer F, Zhang L, Fletcher CD, Ribeiro A, Singer S, Italiano A, Neuville A, Houlier A, Chibon F, Coindre JM, Antonescu CR. Consistent SMARCB1 homozygous deletions in epithelioid sarcoma and in a subset of myoepithelial carcinomas can be reliably detected by FISH in archival material. Genes Chromosomes Cancer 2014.

  76. Cheng JX, Tretiakova M, Gong C, Mandal S, Krausz T, Taxy JB. Renal medullary carcinoma: rhabdoid features and the absence of INI1 expression as markers of aggressive behavior. Mod Pathol. 2008;21:647–52.

    Article  CAS  PubMed  Google Scholar 

  77. Gleason BC, Fletcher CD. Myoepithelial carcinoma of soft tissue in children: an aggressive neoplasm analyzed in a series of 29 cases. Am J Surg Pathol. 2007;31:1813–24.

    Article  PubMed  Google Scholar 

  78. Kohashi K, Oda Y, Yamamoto H, Tamiya S, Oshiro Y, Izumi T, Taguchi T, Tsuneyoshi M. SMARCB1/INI1 protein expression in round cell soft tissue sarcomas associated with chromosomal translocations involving EWS: a special reference to SMARCB1/INI1 negative variant extraskeletal myxoid chondrosarcoma. Am J Surg Pathol. 2008;32:1168–74.

    Article  PubMed  Google Scholar 

  79. Agaimy A, Rau TT, Hartmann A, Stoehr R. SMARCB1 (INI1)-negative rhabdoid carcinomas of the gastrointestinal tract: clinicopathologic and molecular study of a highly aggressive variant with literature review. Am J Surg Pathol 2014;38:910–920

    Google Scholar 

  80. Bishop JA, Antonescu CR, Westra WH. SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. Am J Surg Pathol. 2014;38:1282–9.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Agaimy A, Koch M, Lell M, Semrau S, Dudek W, Wachter DL, Knoll A, Iro H, Haller F, Hartmann A. SMARCB1(INI1)-deficient sinonasal basaloid carcinoma: a novel member of the expanding family of SMARCB1-deficient neoplasms. Am J Surg Pathol. 2014;38:1274–81.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Bell D, Hanna EY, Agaimy A, Weissferdt A. Reappraisal of sinonasal undifferentiated carcinoma: SMARCB1 (INI1)-deficient sinonasal carcinoma: a single-institution experience. Virchows Archiv 2015;467:649–656

    Article  Google Scholar 

  83. Zur KB, Brandwein M, Wang B, Som P, Gordon R, Urken ML. Primary description of a new entity, renal cell-like carcinoma of the nasal cavity: van Meegeren in the house of Vermeer. Arch Otolaryngol Head Neck Surg. 2002;128:441–7.

    Article  PubMed  Google Scholar 

  84. Storck K, Hadi UM, Simpson R, Ramer M, Brandwein-Gensler M. Sinonasal renal cell-like adenocarcinoma: a report on four patients. Head Neck Pathol. 2008;2:75–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Moh’d Hadi U, Kahwaji GJ, Mufarrij AA, Tawil A, Noureddine B. Low grade primary clear cell carcinoma of the sinonasal tract. Rhinology. 2002;40:44–7.

    PubMed  Google Scholar 

  86. Brandwein-Gensler M, Wei S. Envisioning the next WHO head and neck classification. Head Neck Pathol. 2014;8:1–15.

    Article  PubMed  PubMed Central  Google Scholar 

  87. Shen T, Shi Q, Velosa C, Bai S, Thompson L, Simpson R, Wei S, Brandwein-Gensler M. Sinonasal renal cell-like adenocarcinomas: robust carbonic anhydrase expression. Hum Pathol. 2015;46:1598–606.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Anatomic Pathology, University of Virginia Health System, Jefferson Park Ave., Box 800214, Charlottesville, VA, 22908, USA

    Edward B. Stelow

  2. Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Justin A. Bishop

Authors
  1. Edward B. Stelow
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Justin A. Bishop
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Edward B. Stelow.

Ethics declarations

Disclosure

Drs. Bishop and Stelow have no conflict of interest.

Research Involving Animal and Human Rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Additional information

Special Issue: World Health Organization Classification Update

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Stelow, E.B., Bishop, J.A. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Nasal Cavity, Paranasal Sinuses and Skull Base. Head and Neck Pathol 11, 3–15 (2017). https://doi.org/10.1007/s12105-017-0791-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12105-017-0791-4

Keywords

Search

Navigation