Clinical study
Spontaneous coronary artery dissection and eosinophilic inflammation: A cause and effect relationship?

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Abstract

Spontaneous coronary artery dissection is described in eight patients 26 to 47 years of age. Six died suddenly, and two died after the onset of chest pain. All had normal heart weights and all had dissection of the left anterior descending coronary artery, which occurred mainly in the outer one third of the media. The adventitia of the dissected artery contained inflammatory infiltrates which were predominantly eosinophilic granulocytes. Forty-six cases previously published in 32 reports are reviewed. It is suggested that adventitial eosinophilic infiltrate may be responsible for spontaneous coronary artery dissection.

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    The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

    1

    From the Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, D.C.

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