The International Journal of Applied Radiation and Isotopes
Automated synthesis of 11C-labelled radiopharmaceuticals: Imipramine, chlorpromazine, nicotine and methionine
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The association between <sup>11</sup>C-methionine uptake, IDH gene mutation, and MGMT promoter methylation in patients with grade II and III gliomas
2020, Clinical RadiologyCitation Excerpt :PET images were obtained using a SET-3000 GCT/X scanner (Shimadzu, Kyoto, Japan) with gadolinium oxyorthosilicate crystals as emission detectors. The 11C-methionine tracer was synthesised in accordance with the method described by Berger et al.25 and injected intravenously at a dose of 111–222 mBq (3–6 mCi). Tracer accumulation was recorded over 15 minutes in 99 transaxial sections spanning the entire brain.
Production of [ <sup>11</sup> C]Formaldehyde by the XeF <inf>2</inf> mediated oxidation of [ <sup>11</sup> C]Methanol and its application in the labeling of α-(N-[ <sup>11</sup> C]Methylamino)isobutyric acid
2019, Applied Radiation and IsotopesCitation Excerpt :[11C]Formaldehyde is a versatile and approved tool in carbon-11 radiopharmaceutical chemistry including ring closure reactions (Nader et al., 1998; Roeda and Dollé, 2003; Van der Mey et al., 2001, 2006; Hooker et al., 2008), electrophilic aromatic substitution (Langer et al., 2005), hydroxymethalation (Aronstein, 1949), Mannich reaction (Berger et al., 1979), and reductive methylation (Straatmann and Welch, 1975; Marazano et al., 1977; Maziére et al., 1977; Mulholland et al., 1988).
N-[<sup>11</sup>CH<inf>3</inf>]Dimethylaminoparthenolide (DMAPT) uptake into orthotopic 9LSF glioblastoma tumors in the rat
2016, Bioorganic and Medicinal Chemistry Letters<sup>11</sup>C-methinine uptake correlates with MGMT promoter methylation in nonenhancing gliomas
2014, Clinical Neurology and NeurosurgeryCitation Excerpt :PET images were obtained using a SET-3000 GCT/X scanner (Shimadzu Corp.) with gadolinium oxyorthosilicate crystals as emission detectors. 11C-methionine tracer was synthesized according to the method described by Berger et al. [16] and injected intravenously at a dose of 111–222 MBq (3–6 mCi). Tracer accumulation was recorded over 15 min in 99 transaxial slices, spanning the entire brain.