Elsevier

Virology

Volume 16, Issue 4, April 1962, Pages 501-504
Virology

Discussion and preliminary report
Classification of human enteroviruses

https://doi.org/10.1016/0042-6822(62)90233-7Get rights and content

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    The traditional approach to the taxonomic classification of the Enteroviruses was based on schemes using pathogenicity in humans and animals, patterns of replication in cell culture, and neutralization testing [2,4,5]. The ultimate measure of antigenic relatedness of new viral isolates was based on the generation of antisera against a new serotype and reciprocal cross-neutralization testing using a complete panel of prototype enterovirus strains and antisera [5]. Although useful, this approach resulted in the inclusion of nonenteroviral isolates and misclassification of enterovirus strains within the four original species (Poliovirus, Coxsackievirus type A, Coxsackievirus type B, Echovirus) that constituted the genus Enterovirus.

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