Original contributionExophytic variant of fibrous dysplasia (fibrous dysplasia protuberans)
References (21)
- et al.
Fibrous dysplasia
Orthop Clin North Am
(1977) Enchondroma protuberans masquerading as osteochondroma
Hum Pathol
(1982)Polyostotic fibrous dysplasia
Arch Surg
(1938)- et al.
Fibrous dysplasia of bone. A condition affecting one, several or many bones, the graver cases of which may present abnormal pigmentation of skin, premature sexual development, hyperthyroidism or still other extraskeletal abnormalities
Arch Pathol
(1942) Fibrous dysplasia of bone
Bull New York Acad Med
(1946)- et al.
The natural history of fibrous dysplasia. An orthopaedic, pathological, and roentgenographic study
J Bone Joint Surg [Am]
(1962) Tuberous sclerosis, neurofibromatosis, and fibrous dysplasia
- et al.
Enchondroma protuberans of the rib
Skeletal Radiol
(1985) - et al.
Enchondroma protuberans. Report of a case and its distinction from chondrosarcoma and osteochondroma adjacent to an enchondroma
Skeletal Radiol
(1990) - et al.
Case report 784
Skeletal Radiol
(1993)
Cited by (34)
Benign fibro-osseous tumors of bone: clinicopathological findings and differential diagnosis
2022, Diagnostic HistopathologyCitation Excerpt :Assessment of amplification of MDM2 by fluorescence in-situ hybridization can be helpful in that parosteal OSA is often positive, and protuberant fibro-osseous lesion is negative.6 FD is distinguished from protuberant fibro-osseous lesion by virtue of its intramedullary location and configuration of the lesional bone.19 Ossifying fibroma (OF) is a benign fibro-osseous neoplasm that affects the craniofacial skeleton.3
Fibrous and Fibro-Osseous Lesions of Bone
2021, Surgical Pathology ClinicsCitation Excerpt :They are MDM2 positive by IHC and show MDM2 amplification. FD is an intramedullary expansile mass and has only rarely been described to expand beyond the cortical surface (FD protuberans).56 Osteoma typically shows dense bone deposition with only scant loose fibrovascular tissue.
Histopathology of fibro-osseous and cystic tumors of bone
2020, Diagnostic HistopathologyCitation Excerpt :They often harbor MDM2 positivity by IHC and MDM2 amplification by FISH. Fibrous dysplasia is an intramedullary expansile mass and has only rarely been described to expand beyond the cortical surface (fibrous dysplasia protuberans).63 Osteoma typically shows dense bone deposition with only scant loose fibrovascular tissue.
Minute mesenchymal chondrosarcoma within osteochondroma: an unexpected diagnosis confirmed by HEY1-NCOA2 fusion
2018, Human PathologyCitation Excerpt :The nature of the exophytic bony structure that contained MCS deserves discussion. Although we initially considered the possibility of a protuberant growth of sarcoma tissue that originated in the eccentric portion of the parent bone, akin to fibrous dysplasia protuberans [8] or enchondroma protuberans [9], this theory seems unlikely because the MCS was restricted to the apical site of this exophytic growth, with the medullary cavity of the parent rib and the neck tissue of the excrescence being spared (Fig. 2A). Periosteal MCS was another differential diagnosis; however, periosteal MCS grows on the surface of the cortex [3], and the findings of the present case (ie, a clear cortical and medullary continuity, illustrated in Figs. 1D and I and 2A) did not support such a designation.
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Dr Ishida is a visiting research fellow at Montefiore Medical Center supported by the Japan Society for the Promotion of Science, Postdoctoral Fellowships for Research Abroad, Tokyo, Japan.