LETTERS to the EDITORMagnetic resonance spectroscopy of multiple sclerosis: in-vivo detection of myelin breakdown products
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Cited by (69)
Derivative NMR spectroscopy for J-coupled resonances in analytical chemistry and medical diagnostics
2021, Advances in Quantum ChemistryCitation Excerpt :For instance, differentiating chronic and acute multiple sclerosis using MRS may be influenced by interpretation of spectra in the presence of macromolecules. Thus, several earlier medical investigations [77–84] classified some lesions as acute based on the detected elevated levels of the main metabolites at chemical shifts that are close to the resonant frequencies of lipids. The concern here is that lipids might be among the significant contributors to the main metabolites’ elevated levels.
Metabolic profile of PML lesions in patients with and without IRIS an observational study
2012, NeurologyCitation Excerpt :Cho is a cell membrane component and is elevated in the setting of increased membrane turnover. An elevated Cho/Cr ratio has been found in other demyelinating and inflammatory processes such as MS, ADEM, and acute experimental allergic encephalomyelitis.17,21,28,34–36 Because elevated Cho was associated with CE, this biomarker by itself is not helpful to distinguish patients with IRIS from patients without IRIS.
Magnetic Resonance Imaging of Myelin
2007, NeurotherapeuticsCitation Excerpt :Quantitative MT (qMT) studies investigating F, which is partially made up of myelin, and the MT rate (kfor), have found both measures to be decreased in MS lesions,26,46,164,165 attributed to changes in myelination. Magnetic resonance spectroscopy has detected a strong lipid peak in acute lesions attributed to myelin breakdown product during demyelination.166–168 Increases in Cho have also been seen in lesions167–170 and have been described to antedate lesion appearance on conventional MR.171 Such increases in choline may be related to increased turnover of choline-containing myelin membrane phospholipids and cellular inflammation.