Motoric signs of CNS dysfunction associated with alcohol and cocaine withdrawal

doi:10.1016/0165-1781(93)90056-M

Psychiatry Research

Volume 47, Issue 1, April 1993, Pages 69-77

https://doi.org/10.1016/0165-1781(93)90056-M Get rights and content

Abstract

Measures of hand tremor and body sway were recorded from 6 alcohol-dependent (AD) and 16 cocaine-dependent (CD) patients after 1, 3, and 12 weeks of verified abstinence. The same measures were recorded from 15 nonpatient control subjects after comparable intervals. Hand tremor was transduced via an accelerometer. Body sway was transduced by a force-sensitive platform. Analyses revealed different patterns of motoric dysfunction in the AD and CD groups. AD patients exhibited enhanced hand tremor during a pointing task and enhanced body sway. Both of these abnormalities remitted with continued abstinence. CD patients exhibited enhanced and unchanging levels of resting tremor across the first 12 weeks of abstinence, but they had normal levels of body sway and action tremor. These results are interpreted as reflicting a subclinical cerebellar dysfunction in recovering AD patients, and a subclinical extrapyramidal dysfunction in the CD counterparts.

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Motoric signs of CNS dysfunction associated with alcohol and cocaine withdrawal

Abstract

Lancet

Alcohol

Psychiatry Research

Finger tremor in alcoholic patients

Journal of Neurology, Neurosurgery, and Psychiatry

New concepts in cocaine addiction: The dopamine depletion hypothesis

Neuroscience and Biobehavioral Research

An extension of Box's results on the normality of the F distribution in multivariate analysis

Annals of Mathematical Statistics

Disorders of the Cerebellum

Tremor in chronic alcoholism

Neurology

An extrapyramidal choreiform syndrome caused by amphetamine addiction

Journal of Neurology, Neurosurgery, and Psychiatry