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2016, Journal of Clinical NeuroscienceCitation Excerpt :Glioblastoma most commonly presents on imaging as a single peripherally enhancing lesion in an adult patient, although multiple foci of enhancement embedded within a larger region of T2-weighted signal abnormality (multifocal glioblastoma), or even discrete enhancing regions without evidence of connecting tumour (multicentric glioblastoma), are recognised presentations. In such cases, metastatic disease is often considered to be the likely diagnosis, which may delay the diagnosis while efforts are made to determine the primary site of the presumed metastatic disease [1]. As treatment of extracranial malignancy continues to improve, glioblastoma will be seen more commonly in patients with a prior history of cancer, and should remain a diagnostic differential, both to optimise MRI sequences and for appropriate surgical planning.
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