Review articleNeural and behavioral substrates of mood and mood regulation
Introduction
This article summarizes the deliberations and recommendations of the workgroup on the Neural and Behavioral Substrates of Mood and Mood Regulation. The article is divided into two major sections. In the first section, we summarize the current status of the field, present our vision for the future, and in so doing, discuss the various challenges and available opportunities. The second section contains specific recommendations for National Institute of Mental Health (NIMH) priorities in these areas. In each section, we consider research using the following four approaches, which together constituted the subject matter of this workgroup: 1) behavioral and cognitive; 2) neurobiological; 3) computational; and 4) developmental.
Section snippets
Behavioral and cognitive approaches
Research in this area has generated some consistent findings regarding the course and characteristics of depression (Abramson et al 2001) and bipolar disorder (BPD). Eight of these findings are enumerated here. We then describe our current knowledge base of cognitive and psychosocial processes involved in depression and BPD onset and maintenance. Finally, we explore opportunities for future research.
Recommendations for NIMH priorities
We provide recommendations in five specific areas: 1) the behavioral domain; 2) the neural domain; 3) the domain of behavioral-neural interaction; 4) training; and 5) dissemination.
Acknowledgements
This manuscript is one of ten prepared by workgroups under the auspices of the National Institute of Mental Health (NIMH) strategic planning initiative for mood disorders research. Each of the workgroups was given the specific charge to 1) review the state of their assigned area; 2) identify gaps and state a vision of where the field should be going and why; and 3) make general recommendations for NIMH to consider regarding research initiatives that would advance and improve the knowledge and
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