Elsevier

The Journal of Pediatrics

Volume 123, Issue 5, November 1993, Pages 718-724
The Journal of Pediatrics

Original article
Transient ischemic cerebral lesions during induction chemotherapy for acute lymphoblastic leukemia

https://doi.org/10.1016/S0022-3476(05)80845-5Get rights and content

Ninety children were treated for acute lymphoblastic leukemia or non-Hodgkin lymphoma during 1986 through 1992 in the Children's Hospital, University of Helsinki, in Finland. During induction chemotherapy, nine of the children had visual hallucinations progressing to confusion and seizure. The symptoms were often preceded by severe constipation and significantly elevated blood pressure. Neuroradiologic examinations showed bilateral cortical or subcortical white matter lesions. Despite the strokelike manifestations, the lesions were reversible. The triangular shape and location of the lesions in the watershed areas between the major cerebral arteries suggest vascular ischemia as the cause.

References (18)

There are more references available in the full text version of this article.

Cited by (36)

  • Posterior reversible encephalopathy syndrome

    2014, Seminars in Ultrasound, CT and MRI
    Citation Excerpt :

    It is noteworthy that cerebellar involvement is commonly seen (35%) in PRES associated with autoimmune conditions.18 Many other conditions have been associated with PRES including chemotherapy, typically in the setting of high-dose regimens and multidrug therapy.37-40 Additional conditions associated with PRES include, but are not limited to, medical renal disease, cocaine use, methamphetamine use, anaphylaxis, and alcohol withdrawal.17

  • Predisposing factors of posterior reversible encephalopathy syndrome in acute childhood leukemia

    2012, Pediatric Neurology
    Citation Excerpt :

    So far, several cases of posterior reversible encephalopathy syndrome that occurred during treatment of acute leukemia have been reported. However, the literature comprises mainly case reports or small case series [10-26]. This study was designed to investigate clinical manifestations, radiographic features, predisposing factors, and long-term neurologic and radiologic outcomes of posterior reversible encephalopathy syndrome as a complication during the treatment of acute childhood leukemia.

  • Posterior reversible encephalopathy syndrome in paediatric leukaemia

    2010, European Journal of Paediatric Neurology
    Citation Excerpt :

    Three out of four patients had gastrointestinal complaints preceding their seizure, ranging from abdominal pain in the third case to paralytic ileus in case four. This is reported in 12 cases in literature as well.2,4,10,13 Vincristine (VCR)-induced autonomic dysfunction might play a role.

  • Stroke in Childhood

    2004, Practical Strategies in Pediatric Diagnosis and Therapy
View all citing articles on Scopus
View full text