Letters to the EditorTrials of streptokinase in severe acute ischaemic stroke
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2008, Handbook of Clinical NeurologyCitation Excerpt :Hemorrhage occurred in both lobar and deep hemispheric regions and was associated with a 45% mortality rate (Clark et al., 1997). Trials of intravenous streptokinase have shown significantly higher rates of ICH ranging from 6% to 21% with high mortality (Donnan et al., 1995; Multicentre Acute Stroke Trial—Italy [MAST‐I] Group, 1995; Multicenter Acute Stroke Trial—Europe Study Group, 1996). This may be due to an inappropriately high dose of drugs for cerebrovascular disease or the longer‐lasting fibrinolytic effect of streptokinase compared with tPA (Clark et al., 1997).
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