Short communicationAMPA-Induced suppression of oligodendroglial gene expression in neonatal rat brain
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Acknowledgements
Supported by USPHS grants NS 35059 and 40835 (to F.S.S. and J.D.E.B.). Drs. R. Skoff and L. Carlock provided helpful advice regarding the design of PLP and MBP primers.
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2012, Pharmacology Biochemistry and BehaviorCitation Excerpt :In addition to playing an important role in the pathophysiology of neuronal death, glutamate, acting at ionotropic GluRs, has trophic functions in the developing brain by regulating neuronal development, proliferation and migration of progenitor cells, synaptic plasticity, and neuronal survival (Cull-Candy et al., 2001; Haydar et al., 2000; LoTurco et al., 1995). After an injection of AMPA in P7 rats, bilateral periventricular gray and WM injury were observed (Xu et al., 2001). However, during the follow-up period, one day and one week after the injection, the number of proliferating cells in the SVZ was markedly increased (Xu et al., 2005).
Excitotoxic lesions of the developing brain
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