Archival ReportPositron Emission Tomography Quantification of Serotonin-1A Receptor Binding in Medication-Free Bipolar Depression
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Participants
Thirty-two patients who presented in a MDE and met DSM-IV criteria for bipolar I or bipolar II disorder on Structured Clinical Interview for DSM-IV Axis I Disorders Patient Edition (SCID-I/P) (12), psychiatric interview, and chart review were enrolled. Forty-seven healthy volunteer control participants were also enrolled if free of Axis I diagnosis by Structured Clinical Interview for DSM-IV Axis I Disorders Non-Patient Edition SCID-I/NP (12) and without history of mood or psychotic disorder or
Results
The healthy volunteer and bipolar disorder groups were of comparable age (t = −.14; p = .89) and sex distribution (X2, p = .87). Table 1 provides sociodemographic and clinical data for the two groups. The ROI analysis of the [Carbonyl-C-11]WAY-100635 PET data revealed expected differences in the binding to 5-HT1A, expressed as BPF, across brain regions [F(12,900) = 976.1, p < .0001].
Discussion
To our knowledge, this is the first published report employing PET to assess 5-HT1A binding in vivo in a homogeneous, nonmedicated, patient sample with bipolar depression. Using the 5-HT1A antagonist radioligand [Carbonyl-C-11]WAY-100635, we identified in bipolar depression higher 5-HT1A BPF, in particular in the raphe autoreceptors and to a lesser degree across all terminal field ROIs. Post hoc analyses indicated the higher 5-HT1A BPF was specific to male bipolar depressed patients compared
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