Archival ReportAtypical Default Network Connectivity in Youth with Attention-Deficit/Hyperactivity Disorder
Section snippets
Participants and Measures
Youth (7–16 years) were recruited with a combination of advertisements, mailings, and clinic outreach. Informed written consent and assent was obtained from parents and children, respectively; all procedures complied with the University Human Investigation Review Board. Twenty-three participants with ADHD and 23 age-matched healthy control participants were included. Data for this study were collected as a large collaborative effort at Oregon Health and Science University, and as such slightly
Sample Overview
Participant characteristics are summarized in Table 1 (see also Table S1 in Supplement 1). Intellectual functioning was in the normal range for both groups, but as is commonly found, the ADHD group had a lower estimated full-scale IQ than the control group. Parent Conners scores were in the clinical range for the ADHD group but in the normal range for the typically developing group. Symptom scores did not vary with age across groups (hyperactivity r = .13, p = .39; Inattention, r = .01, p =
Discussion
We found that correlated spontaneous activity within the default network is reduced in children with ADHD. We further showed that specific functional connections, previously shown as developmentally dynamic (26), were also atypical in children with ADHD. These findings are consistent with perturbation in the typical developmental trajectory of circuit consolidation and suggest that the consolidation of this network over development may play a central role in the pathophysiology of ADHD.
We note
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