Original ArticlePerinatal Acidosis and Hypoxic-Ischemic Encephalopathy in Preterm Infants of 33 to 35 Weeks’ Gestation
Section snippets
Methods
This retrospective cohort study included all inborn infants of 33 to 35 weeks’ gestation who were admitted to the neonatal intensive care unit (NICU) at Parkland Memorial Hospital (PMH) with perinatal acidosis from October 2005 to September 2008. These infants were identified by review of a prospective neonatal database and resuscitation registry8 and included all admissions to the PMH NICU with perinatal acidosis. Umbilical cord arterial blood was routinely sampled on all deliveries at PMH
Results
In 1305 newborns admitted to the PMH NICU at 33 to 35 weeks’ gestation, biochemical screening was performed on umbilical cord blood (n = 1275) or a blood sample obtained within 1 hour of birth (n = 30). Thirty-three newborns (2.5%) were identified with perinatal acidosis that was detected in 32 of the infants with umbilical cord blood sampling. In one newborn, acidosis was detected on the first arterial blood gas within 1 hour of age (Figure; Table I). Overall, 22 of those 33 newborns (67%) met the
Discussion
This retrospective study examined how the biochemical screening criteria and neurological assessment for HIE that are used in full-term infants to assess their eligibility for hypothermia therapy apply to the preterm infant of 33 to 35 weeks’ gestation.1 Overall, 2.5% of these preterm newborns met physiological screening criteria for perinatal acidosis, and 27% of them had neurological signs of moderate to severe HIE on the first day of age. This finding is similar to that seen in term
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L.C. is supported by the National Center for Research Resources (grants KL2RR024983 and UL1 RR024982). The authors declare no conflicts of interest.