Elsevier

Molecular Brain Research

Volume 140, Issues 1–2, 31 October 2005, Pages 120-126
Molecular Brain Research

Short Communication
High intrinsic oxidative stress may underlie selective vulnerability of the hippocampal CA1 region

https://doi.org/10.1016/j.molbrainres.2005.07.018Get rights and content

Abstract

Oxidative stress (OS) causes extensive cell death in the CA1 but not the CA3 region of the hippocampus. We found that the CA1 region of hippocampus explants, cultured under normal conditions, had significantly higher superoxide levels and expressed both anti-oxidant genes and genes related to the generation of reactive oxygen species at significantly higher levels than the CA3. These observations were indicative of high intrinsic OS in CA1.

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Acknowledgments

We thank Dr. M. L. Michaelis for scientific advice and editorial assistance and Ms. J. Vega for assistance in the preparation of the manuscript. The support of the Higuchi Biosciences Center/Center for Neurobiology and Immunology Research, the University of Kansas, is acknowledged. The work was supported by grants from NIA AG12993, NICHD HD02528, the Kansas Technology Enterprise Corporation and Miller Hadwiger Fund.

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