Elsevier

Translational Oncology

Volume 12, Issue 3, March 2019, Pages 523-538
Translational Oncology

Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment1

https://doi.org/10.1016/j.tranon.2018.11.011Get rights and content
Under a Creative Commons license
open access

Abstract

Primary central nervous system lymphoma (PCNSL) is a group of extranodal non-Hodgkin lymphoma that exhibits specific biological characteristics and clinical behavior, with an aggressive disease course and unsatisfactory patient outcomes. It is of great importance to identify aberrant genetic loci and important molecular pathways that might suggest potential targets for new therapeutics and provide prognostic information. In this review, we listed various genetic and epigenetic alterations that are involved in PCNSL pathogenesis. In the aspect of treatment, we summarized the related literatures and evaluated the efficacy of surgery, induction chemotherapy, radiotherapy, intrathecal chemotherapy, and autologous stem cell transplantation in PCNSL. We also proposed the possible new agents for recurrent and relapse PCNSL based on the result of recent clinical researches.

Cited by (0)

1

Declarations of interest: none.

1

These authors contributed equally to this work.