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Unsupervised Learning and Adaptation in a Model of Adult Neurogenesis

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Abstract

Adult neurogenesis has long been documented in the vertebrate brain and recently even in humans. Although it has been conjectured for many years that its functional role is related to the renewing of memories, no clear mechanism as to how this can be achieved has been proposed. Using the mammalian olfactory bulb as a paradigm, we present a scheme in which incorporation of new neurons proceeds at a constant rate, while their survival is activity-dependent and thus contingent on new neurons establishing suitable connections. We show that a simple mathematical model following these rules organizes its activity so as to maximize the difference between its responses and can adapt to changing environmental conditions in unsupervised fashion, in agreement with current neurophysiological data.

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References

  • Altman J, Das GD (1965) Post-natal origin of microneurones in the rat brain. Nature 207:953-956.

    Google Scholar 

  • Alvarez-Buylla A, Kirn JR, Nottebohm F (1990) Birth of projection neurons in adult avian brain may be related to perceptual or motor learning. Science 249:1444-1446.

    Google Scholar 

  • Alvarez-Buylla A, Ling CY, Nottebohm F (1992) High vocal center growth and its relation to neurogenesis, neuronal replacement and song acquisition in juvenile canaries. J. Neurobiol. 23:396-406.

    Google Scholar 

  • Alvarez-Buylla A, Lois C (1995) Neuronal stem cells in the brain of adult vertebrates. Stem Cells 13:263-272.

    Google Scholar 

  • Bailey CH, Bartsch D, Kandel ER (1996) Toward a molecular definition of long-term memory storage. Proc. Natl. Acad. Sci. USA 93:13445-13452.

    Google Scholar 

  • Barnea A, Nottebohm F (1994) Seasonal recruitment of hippocampal neurons in adult free-ranging black-capped chickadees. Proc. Natl. Acad. Sci. USA 91:11217-11221.

    Google Scholar 

  • Buonviso N, Chaput M (2000) Olfactory experience decreases responsiveness of the olfactory bulb in the adult rat. Neurosci. 95:325-332.

    Google Scholar 

  • Chechik G, Meilijson I, Ruppin E (1999) Neuronal regulation: A mechanism for synaptic pruning during brain maturation. Neural Computation 11:2061-2080.

    Google Scholar 

  • Corotto FS, Henegar JR, Maruniak JA (1994) Odor deprivation leads to reduced neurogenesis and reduced neuronal survival in the olfactory bulb of the adult mouse. Neuroscience 61:739-744.

    Google Scholar 

  • Cummings DM, Henning HE, Brunjes PC (1997) Olfactory bulb recovery after early sensory deprivation. J. Neurosci. 17:7433-7440.

    Google Scholar 

  • Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH (1998) Neurogenesis in the adult human hippocampus. Nature Medicine 4:1313-1317.

    Google Scholar 

  • Frazier-Cierpial L, Brunjes PC (1989) Early postnatal cellular proliferation and survival in the olfactory bulb and rostral migratory stream of normal and unilaterally odor-deprived rats. J. Comp. Neurol. 289:481-492.

    Google Scholar 

  • Friedrich RW, Laurent G (2001) Dynamic optimization of odor representations by slow temporal patterning of mitral cell activity. Science 291:889-894.

    Google Scholar 

  • Gheusi G, Cremer H, McLean H, Chazal G, Vincent JD, Lledoet PM (2000) Importance of newly generated neurons in the adult olfactory bulb for odor discrimination. Proc. Natl. Acad. Sci. USA 97:1823-1828.

    Google Scholar 

  • Goldman SA (1998) Adult neurogenesis: from canaries to the clinic. J. Neurobiol. 36:267-286.

    Google Scholar 

  • Gould E, Beylin A, Tanapat P, Reeves A, Shors TJ (1999) Learning enhances adult neurogenesis in the hippocampal formation. Nature Neuroscience 2:260-265.

    Google Scholar 

  • Gould E, Reeves AJ, Fallah M, Tanapat P, Gross CG, Fuchs E (1999) Hippocampal neurogenesis in adult Old World primates. Proc. Natl. Acad. Sci. USA 96:5263-5267.

    Google Scholar 

  • Gould E, Reeves AJ, Graziano MSA, Gross CG (1999) Neurogenesis in the neocortex of adult primates. Science 286:548-552.

    Google Scholar 

  • Guthrie KM, Wilson DA, Leon M (1990) Early unilateral deprivation modifies olfactory bulb function. J. Neurosci. 10:3402-3412.

    Google Scholar 

  • Hildebrand JG, Shepherd GM (1997) Mechanisms of olfactory discrimination: Converging evidence for common principles across phyla. Ann. Rev. Neurosci. 20:595-631.

    Google Scholar 

  • Hopfield JJ (1991) Olfactory computation and object recognition. Proc. Natl. Acad. Sci. USA 88:6462-6466.

    Google Scholar 

  • Katz LC, Shatz CJ (1996) Synaptic activity and the construction of cortical circuits. Science 274:1133-1138.

    Google Scholar 

  • Kempermann G, Kuhn HG, Gage FH (1997) More hippocampal neurons in adult mice living in an enriched environment. Nature 386:493-495.

    Google Scholar 

  • Kirn JR, Fishman Y, Sasportas K, Alvarez-Buylla A, Nottebohm F (1999) Fate of new neurons in adult canary high vocal center during the first 30 days after their formation. J. Comp. Neurol. 411:487-494.

    Google Scholar 

  • Kirn J, O'Loughlin B, Kasparian S, Nottebohm F (1994) Cell death and neuronal recruitment in the high vocal center of adult male canaries are temporally related to changes in song. Proc. Natl. Acad. Sci. USA 91:7844-7848.

    Google Scholar 

  • Kirschenbaum B, Doetsch F, Lois C, Alvarez-Buylla A (1999) Adult subventricular zone neuronal precursors continue to proliferate and migrate in the absence of the olfactory bulb. J. Neurosci. 19:2171-2180.

    Google Scholar 

  • Koch C (1998) Biophysics of Computation. Oxford University Press, New York.

    Google Scholar 

  • Laurent G, Wher M, Davidowitz H (1996) Temporal representation of odors in an olfactory network. J. Neurosci. 16:3837-3847.

    Google Scholar 

  • Lois C, Alvarez-Buylla A (1994) Long-distance neuronal migration in the adult mammalian brain. Science 264:1145-1148.

    Google Scholar 

  • Malnic B, Hirono J, Sato T, Buck LB (1999) Combinatorial receptor codes for odors. Cell 96:713-723.

    Google Scholar 

  • Mombaerts P, Wang F, Dulac C, Chao SK, Nemes A, Mendelsohn M, Edmondson J, Axel R (1996) Visualizing an olfactory sensory map. Cell 87:675-686.

    Google Scholar 

  • Mori K, Nagao H, Sasaki YF (1998) Computation of molecular information in mammalian olfactory systems. Network: Comput. Neural Syst. 9:R79-R102.

    Google Scholar 

  • Petreanu LT, Alvarez-Buylla A (2000) An early wave of cell death of newly generated granule neurons in the adult mouse olfactory bulb. (Abstract) Soc. Neurosci. Abs.: 6120.

  • Rosselli-Austin L, Altman J (1979) The postnatal development of the main olfactory bulb of the rat. J. Devel. Physiol. 1:295-313.

    Google Scholar 

  • Shannon CE (1993) Communication in the presence of noise. In: Sloane NJA, Wyner AD, eds. CE Shannon Collected Papers. IEEE Press, New York.

    Google Scholar 

  • Vassar R, Chao SK, Sitcheran R, Nunez JM, Vosshall LB, Axel R (1994) Topographic organization of sensory projections to the olfactory bulb. Cell 79:981-991.

    Google Scholar 

  • Verhage M, Maia AS, Plomp JJ, Brussaard AB, Heeroma JH, Vermeer H, Toonen RF, Hammer RE, van den Berg TK, Missler M, Geuze HJ, Sudhof TC (2000) Synaptic assembly of the brain in the absence of neurotransmitter secretion. Science 287: 864-869.

    Google Scholar 

  • Woolf TB, Shepherd GM, Greer CA (1991) Local information processing in dendritic trees: Subsets of spines in granule cells of the mammalian olfactory bulb. J. Neurosci. 11:1837-1854.

    Google Scholar 

  • Yokoi M, Mori K, Nakanishi S (1995) Refinement of odor molecule tuning by dendrodendritic synaptic inhibition in the olfactory bulb. Proc. Natl. Acad. Sci. USA 92:3371-3375.

    Google Scholar 

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Cecchi, G.A., Petreanu, L.T., Alvarez-Buylla, A. et al. Unsupervised Learning and Adaptation in a Model of Adult Neurogenesis. J Comput Neurosci 11, 175–182 (2001). https://doi.org/10.1023/A:1012849801892

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