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Spinal cord injury

Visualizing plasticity and repair in the injured CNS

The heterogeneity of traumatic spinal cord injury necessitates large clinical trials to differentiate natural improvements from enhanced recovery due to therapeutic intervention. Recent development of an imaging biomarker to visualize changes in the corticospinal motor system could offer the opportunity to directly visualize anatomical evidence of repair, regeneration and plasticity.

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References

  1. Sekhon, L. H. & Fehlings, M. G. Epidemiology, demographics, and pathophysiology of acute spinal cord injury. Spine (Phila. Pa 1976) 26, S2–S12 (2001).

    Article  CAS  Google Scholar 

  2. Fawcett, J. W. et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials. Spinal Cord 45, 190–205 (2007).

    Article  CAS  Google Scholar 

  3. Steeves, J. D. et al. Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures. Spinal Cord 45, 206–221 (2007).

    Article  CAS  Google Scholar 

  4. Freund, P. et al. MRI investigation of the sensorimotor cortex and the corticospinal tract after acute spinal cord injury: a prospective longitudinal study. Lancet Neurol. 12, 873–881 (2013).

    Article  CAS  Google Scholar 

  5. Stroman, P. W. et al. Advanced MR imaging techniques and characterization of residual anatomy. Clin. Neurol. Neurosurg. 114, 460–470 (2012).

    Article  CAS  Google Scholar 

  6. Simpson, L. A., Eng, J. J., Hsieh, J. T. & Wolfe, D. L. The health and life priorities of individuals with spinal cord injury: a systematic review. J. Neurotrauma 29, 1548–1555 (2012).

    Article  Google Scholar 

  7. Cadotte, D. W. et al. Plasticity of the injured human spinal cord: insights revealed by spinal cord functional MRI. PLoS ONE 7, e45560 (2012).

    Article  CAS  Google Scholar 

  8. Curt, A. et al. Changes of non-affected upper limb cortical representation in paraplegic patients as assessed by fMRI. Brain 125, 2567–2578 (2002).

    Article  Google Scholar 

  9. Wilson, J. R., Forgione, N. & Fehlings, M. G. Emerging therapies for acute traumatic spinal cord injury. CMAJ 185, 485–492 (2013).

    Article  Google Scholar 

  10. Cadotte, D. W. & Fehlings, M. G. Spinal cord injury: a systematic review of current treatment options. Clin. Orthop. Relat. Res. 469, 732–741 (2011).

    Article  Google Scholar 

Download references

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Correspondence to Michael G. Fehlings.

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Cadotte, D., Fehlings, M. Visualizing plasticity and repair in the injured CNS. Nat Rev Neurol 9, 546–547 (2013). https://doi.org/10.1038/nrneurol.2013.190

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