Abstract
The use of cyclosporin A has been associated with several side-effects, including neurotoxicity. The mechanism of toxicity is not well known. We report two patients treated with cyclosporin A who developed lesions in the cerebral white matter associated with abnormally elevated cerebral blood flow velocities on transcranial doppler ultrasound and abnormal vascular appearance on magnetic resonance angiography. Bone Marrow Transplantation (2000) 26, 801–804.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Pace MT, Slovis TL, Kelly JK, Abella SD . Cyclosporin A toxicity: MRI appearance of the brain Pediatr Radiol 1995 25: 180–183
Langford CA, Klippel JH, Balow JE et al. Use of cytotoxic agents and cyclosporine in the treatment of auto-immune disease, part 1 Ann Intern Med 1998 128: 1021–1028
Langford CA, Klippel JH, Balow JE et al. Use of cytotoxic agents and cyclosporine in the treatment of auto-immune disease, part 2 Ann Intern Med 1998 129: 49–58
Bartynski WS, Grabb BC, Zeigler Z et al. Watershed imaging features and clinical vascular injury in cyclosporin A neurotoxicity J Comput Assist Tomogr 1997 21: 872–880
Port JD, Beauchamp NJ . Reversible intracerebral pathologic entities mediated by vascular autoregulatory dysfunction Radiographics 1998 18: 353–367
Truwit CL, Denaro CP, Lake JR, DeMarco T . MR Imaging of reversible Cyclosporin A-induced neurotoxicity AJNR 1991 12: 651–659
Sloane JP, Lwin KY, Gore ME et al. Disturbance of blood-brain barrier after bone marrow transplantation Lancet 1985 2: 280–281
Reece DE, Frei-Lahr DA, Shepherd JD et al. Neurologic complications in allogeneic bone marrow transplant patients receiving cyclosporin Bone Marrow Transplant 1991 8: 393–401
Tatsuhiko I, Tsuneo S, Shoichi I et al. MR angiography of cerebral vasospasm in pre-eclampsia AJNR 1995 16: 1344–1346
Steg RE, Kessinger A, Wszolek ZK . Cortical blindness and seizures in a patient receiving FK506 after bone marrow transplantation Bone Marrow Transplant 1999 23: 959–962
Author information
Authors and Affiliations
Additional information
Division of Neurology, Duke University Medical Center, Durham, NC, USA
Rights and permissions
About this article
Cite this article
Shbarou, R., Chao, N. & Morgenlander, J. Cyclosporin A-related cerebral vasculopathy. Bone Marrow Transplant 26, 801–804 (2000). https://doi.org/10.1038/sj.bmt.1702603
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1702603
Keywords
This article is cited by
-
Accidental Overdose of Oral Cyclosporine in Haematopoietic Stem Cell Transplantation: A Case Report and Literature Review
Drug Safety - Case Reports (2015)
-
Vasospasm is a significant factor in cyclosporine-induced neurotoxicity: Case report
BMC Neurology (2010)
-
Mesial temporal sclerosis – a late complication in four allogeneic pediatric recipients with persistent seizures after an acute episode of cyclosporine-A neurotoxicity
Bone Marrow Transplantation (2003)