Am J Perinatol 2015; 32(06): 555-564
DOI: 10.1055/s-0034-1396692
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Does Near-Infrared Spectroscopy Identify Asphyxiated Newborns at Risk of Developing Brain Injury During Hypothermia Treatment?

Shuo Peng
1   Division of Newborn Medicine, Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada
,
Elodie Boudes
1   Division of Newborn Medicine, Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada
,
Xianming Tan
2   Biostatistics Core Facility, Research Institute, McGill University Health Centre, Montreal, Canada
,
Christine Saint-Martin
3   Department of Radiology, Montreal Children's Hospital, McGill University, Montreal, Canada
,
Michael Shevell
4   Division of Pediatric Neurology, Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada
,
Pia Wintermark
1   Division of Newborn Medicine, Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada
5   Division of Newborn Medicine, Boston Children's Hospital, Boston
› Author Affiliations
Further Information

Publication History

14 June 2014

07 October 2014

Publication Date:
16 January 2015 (online)

Abstract

Objective The aim of this article is to assess whether near-infrared spectroscopy (NIRS) identifies, during hypothermia treatment, the asphyxiated newborns who later develop brain injury.

Study Design In this study, asphyxiated newborns, for whom later brain injury was defined by brain imaging and/or autopsy results, were monitored by NIRS during therapeutic hypothermia. We compared regional cerebral oxygenation saturation (rSO2) measured by NIRS at key time points for newborns who developed or did not develop later brain injury.

Results A total of 18 asphyxiated newborns treated with hypothermia were enrolled. rSO2 was higher in the asphyxiated newborns who developed later brain injury. Sensitivity within the first 10 hours of hypothermia treatment for an adverse outcome was 100% (95% confidence interval [CI], 70–100%) and specificity was 83% (95% CI, 36–99%).

Conclusions NIRS appears to identify asphyxiated newborns at risk of developing brain injury as early as the first 10 hours of hypothermia treatment. Thus, NIRS may have an important role as an early outcome predictor in this population.

 
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