Neuropediatrics 1992; 23(5): 263-267
DOI: 10.1055/s-2008-1071355
Case report

© Georg Thieme Verlag KG Stuttgart · New York

Proton NMR Spectroscopy of Canavan's Disease

P. B. Barker1 , R. N. Bryan1 , A. J. Kumar1 , S.  Naidu2
  • 1Department of Radiology, Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD 21205, USA
  • 2Department of Neurology, Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD 21205, USA
Further Information

Publication History

Publication Date:
19 March 2008 (online)

Abstract

Proton Nuclear Magnetic Resonance (NMR) spectroscopy was used to quantitatively determine cerebral N-Acetyl Aspartate (NAA) concentrations in four patients with Canavan's disease and in four age-matched control subjects. Macroscopic NAA concentrations (µmol/gm wet weight) were not found to be significantly different from controls. Reduced levels of choline and creatine were observed in all patients, and increased levels of lactate and inositol in the eldest three patients.

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