Progressive multifocal leukoencephalopathy demonstrating contrast enhancement on MRI and uptake of thallium-201: a case report

J D Port; S Miseljic; R R Lee; S Z Ali; T L Nicol; W Royal 3rd; B B Chin

doi:10.1007/s002340050862

Progressive multifocal leukoencephalopathy demonstrating contrast enhancement on MRI and uptake of thallium-201: a case report

Neuroradiology. 1999 Dec;41(12):895-8. doi: 10.1007/s002340050862.

Authors

J D Port¹, S Miseljic, R R Lee, S Z Ali, T L Nicol, W Royal 3rd, B B Chin

Affiliation

¹ Russell H. Morgan Department of Radiology, Johns Hopkins Medical School, Baltimore, MD 21287, USA.

PMID: 10639663
DOI: 10.1007/s002340050862

Abstract

We describe a patient with AIDS who presented with focal neurological symptoms, and who had contrast-enhancing brain lesions on MRI which demonstrated increased thallium-201 uptake on SPECT. These findings were consistent with lymphoma; however, brain biopsy established a diagnosis of progressive multifocal leukoencephalopathy (PML). To our knowledge, this is the first reported case of PML with increased thallium-201 uptake on brain SPECT.

Publication types

Case Reports

MeSH terms

AIDS-Related Opportunistic Infections / diagnosis*
AIDS-Related Opportunistic Infections / diagnostic imaging
AIDS-Related Opportunistic Infections / pathology
Adult
Brain / diagnostic imaging
Brain / pathology
Female
Humans
Leukoencephalopathy, Progressive Multifocal / diagnosis*
Leukoencephalopathy, Progressive Multifocal / diagnostic imaging
Leukoencephalopathy, Progressive Multifocal / pathology
Magnetic Resonance Imaging*
Thallium Radioisotopes
Tomography, Emission-Computed, Single-Photon*

Substances

Thallium Radioisotopes