An alternative explanation of the origin of the signal in diffusion-weighted MRI

Neuroradiology. 2000 Feb;42(2):96-8. doi: 10.1007/s002340050022.

Abstract

I formulated an alternative explanation for the origin of the signal in diffusion-weighted MRI (DWI) and tested it in a simple experimental model using gelatin. My findings indicate that the signal in DWI is influenced by the passage of water from the sol to the gel state, independently of the presence of cell structures or membrane-dependent diffusion.

MeSH terms

  • Body Water / chemistry
  • Brain / anatomy & histology
  • Diffusion
  • Gelatin / chemistry
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Magnetic Resonance Imaging / methods*
  • Monosaccharides / chemistry
  • Proteins / chemistry
  • Water / chemistry

Substances

  • Monosaccharides
  • Proteins
  • Water
  • Gelatin