Abstract
T1 hypointensities are lesions that are hypointense on moderately T1-weighted conventional spin-echo sequences and serve as markers of matrix destruction and axonal loss. They correlate better with clinical disability than T2-weighted images, are found in patients with progressive multiple sclerosis, and can be used as surrogate outcome measures in treatment trials.
MeSH terms
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Axons / pathology
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Brain / pathology
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Diagnosis, Differential
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Disability Evaluation
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Echo-Planar Imaging
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Humans
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Image Enhancement
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Magnetic Resonance Imaging*
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Magnetic Resonance Spectroscopy
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Multiple Sclerosis / diagnosis*
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Multiple Sclerosis / pathology
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Multiple Sclerosis, Chronic Progressive / diagnosis
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Multiple Sclerosis, Chronic Progressive / pathology
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Retrograde Degeneration / diagnosis*
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Retrograde Degeneration / pathology