Hyperhomocysteinemia as risk factor for ischemic and hemorrhagic stroke in newborn infants

Marije Hogeveen; Henk J Blom; Marjolein Van Amerongen; Bas Boogmans; Ingrid M Van Beynum; Margot Van De Bor

doi:10.1067/mpd.2002.126598

Hyperhomocysteinemia as risk factor for ischemic and hemorrhagic stroke in newborn infants

J Pediatr. 2002 Sep;141(3):429-31. doi: 10.1067/mpd.2002.126598.

Authors

Marije Hogeveen¹, Henk J Blom, Marjolein Van Amerongen, Bas Boogmans, Ingrid M Van Beynum, Margot Van De Bor

Affiliation

¹ Department of Pediatrics, University of Nijmegen Medical Center, Nijmegen, The Netherlands.

PMID: 12219068
DOI: 10.1067/mpd.2002.126598

Abstract

We studied the association between plasma total homocysteine concentrations and the occurrence of stroke in newborn infants (n = 24). Newborn infants with stroke had significantly higher mean total homocysteine concentrations compared with 94 healthy newborn infants (9.3 vs 7.4 micromol/L). The odds ratio for neonatal stroke was 3.95 (95" CI 1.53-10.16) at the 80" cutoff level.

MeSH terms

Brain Ischemia / epidemiology
Brain Ischemia / etiology*
Cerebral Hemorrhage / epidemiology
Cerebral Hemorrhage / etiology*
Humans
Hyperhomocysteinemia / complications*
Infant, Newborn
Logistic Models
Netherlands / epidemiology
Retrospective Studies
Risk Factors
Stroke / epidemiology
Stroke / etiology*