Detecting abnormal regional cerebral blood flow in patients with primary Sjögren's syndrome by technetium-99m ethyl cysteinate dimer single photon emission computed tomography of the brain--a preliminary report

W S Huang; P Y Chiu; A Kao; C H Tsai; C C Lee

doi:10.1007/s00296-002-0272-1

Detecting abnormal regional cerebral blood flow in patients with primary Sjögren's syndrome by technetium-99m ethyl cysteinate dimer single photon emission computed tomography of the brain--a preliminary report

Rheumatol Int. 2003 Jul;23(4):174-7. doi: 10.1007/s00296-002-0272-1. Epub 2003 Feb 18.

Authors

W S Huang¹, P Y Chiu, A Kao, C H Tsai, C C Lee

Affiliation

¹ Department of Neurology, China Medical College Hospital, Taichung, Taiwan.

PMID: 12856142
DOI: 10.1007/s00296-002-0272-1

Abstract

Technetium-99m ethyl cysteinate dimer (Tc-99m ECD) brain single photon emission computed tomography (SPECT) was used to detect abnormal regional cerebral blood flow (rCBF) in 32 female patients with primary Sjögren's syndrome (PSS) showing definite neuropsychiatric symptoms/signs and normal brain magnetic resonance imaging (MRI) findings. It demonstrated hypoperfusion brain lesions in 18 (56.3%) of the patients, most frequently in the parietal lobes, and appears to be a sensitive tool for this clinical application.

MeSH terms

Adult
Brain / blood supply
Brain / diagnostic imaging*
Cerebrovascular Circulation / physiology*
Cerebrovascular Disorders / diagnostic imaging*
Cerebrovascular Disorders / etiology
Cysteine / analogs & derivatives*
Female
Humans
Mental Disorders / etiology
Middle Aged
Nervous System Diseases / etiology
Organotechnetium Compounds*
Radiopharmaceuticals*
Sjogren's Syndrome / complications
Sjogren's Syndrome / diagnosis
Sjogren's Syndrome / diagnostic imaging*
Tomography, Emission-Computed, Single-Photon / methods*

Substances

Organotechnetium Compounds
Radiopharmaceuticals
technetium Tc 99m bicisate
Cysteine