Clonal relationship in multifocal non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue (MALT)

Ann Hematol. 2004 Feb;83(2):124-6. doi: 10.1007/s00277-003-0763-5. Epub 2003 Sep 27.

Abstract

To elucidate the progression of gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type, we analyzed a case presenting simultaneously with MALT lymphoma of the stomach and lung, and a gastric high-grade diffuse large lymphoma. The rearranged immunoglobulin heavy chain (IgH) variable regions were analyzed using a polymerase chain reaction (PCR)-based assay. Clonal relationship was shown between the gastric high-grade and the pulmonary low-grade lymphoma. The gastric MALT lymphoma was not related to the other manifestations. Translocation t(11;18) was not detected in the gastric high-grade lymphoma. MALT lymphomas at various locations and with different histologies may derive from a common precursor cell. Lymphomas at identical sites may have different stem cells.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alleles
  • Base Sequence
  • Clone Cells
  • Female
  • Gene Rearrangement, B-Lymphocyte, Heavy Chain / genetics
  • Humans
  • Immunoglobulin Heavy Chains / genetics
  • Lung Neoplasms / genetics
  • Lung Neoplasms / immunology
  • Lymphoma, B-Cell / genetics*
  • Lymphoma, B-Cell / immunology
  • Lymphoma, B-Cell, Marginal Zone / genetics*
  • Lymphoma, B-Cell, Marginal Zone / immunology
  • Lymphoma, Non-Hodgkin / genetics
  • Lymphoma, Non-Hodgkin / immunology
  • Molecular Sequence Data
  • Neoplasms, Multiple Primary / genetics*
  • Neoplasms, Multiple Primary / immunology
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid
  • Stomach Neoplasms / genetics
  • Stomach Neoplasms / immunology

Substances

  • Immunoglobulin Heavy Chains