Abstract
This multi-voxel, phosphorus magnetic resonance spectroscopy ((31)P MRS) study examined the prefrontal cortex (PFC), basal ganglia (BG) and superior temporal (ST) region in 10 children with attention-deficit/hyperactivity disorder (ADHD) and 15 healthy controls. ADHD patients had lower PFC and BG phosphomonoester (PME) levels compared to healthy children. No differences were noted in the ST. These deficits in membrane phospholipid (MPL) precursor levels suggest reduced mass of cellular MPLs due to a possible underdevelopment of neuronal processes and synapses in ADHD.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Attention Deficit Disorder with Hyperactivity / diagnosis
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Attention Deficit Disorder with Hyperactivity / physiopathology*
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Attention Deficit and Disruptive Behavior Disorders / diagnosis
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Attention Deficit and Disruptive Behavior Disorders / physiopathology
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Basal Ganglia / physiopathology*
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Child
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Comorbidity
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Female
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Humans
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Magnetic Resonance Spectroscopy*
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Male
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Membrane Lipids / metabolism*
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Nerve Net / physiopathology
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Neurons / physiology
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Phospholipids / metabolism*
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Phosphorus / metabolism
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Prefrontal Cortex / physiopathology*
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Synapses / physiology
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Temporal Lobe / physiopathology*
Substances
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Membrane Lipids
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Phospholipids
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Phosphorus