Abstract
A patient with human immunodeficiency virus-related posterior fossa progressive multifocal leukoencephalopathy had serial diffusion-weighted imaging using b-values of 1000 and 3000 before and during highly active antiretroviral therapy (HAART). High-b-value images provided a superior definition of the leading edge of the lesion and additional information about the integrity of white matter tracts. Following HAART, there was a marked reduction of lesional apparent diffusion coefficient and reconstitution of anisotropy in the affected middle cerebellar peduncle.
MeSH terms
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Acquired Immunodeficiency Syndrome / complications
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Acquired Immunodeficiency Syndrome / drug therapy*
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Adenine / administration & dosage
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Adenine / analogs & derivatives
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Adult
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Anti-HIV Agents / administration & dosage
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Antiretroviral Therapy, Highly Active*
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Brain / pathology
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Diffusion
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Diffusion Magnetic Resonance Imaging*
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HIV Protease Inhibitors / administration & dosage
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Humans
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Leukoencephalopathy, Progressive Multifocal / drug therapy*
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Leukoencephalopathy, Progressive Multifocal / pathology*
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Leukoencephalopathy, Progressive Multifocal / virology
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Lopinavir
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Male
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Organophosphonates / administration & dosage
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Pyrimidinones / administration & dosage
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Ritonavir / administration & dosage
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Tenofovir
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Zidovudine / administration & dosage
Substances
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Anti-HIV Agents
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HIV Protease Inhibitors
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Organophosphonates
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Pyrimidinones
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Lopinavir
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Zidovudine
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Tenofovir
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Adenine
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Ritonavir