So far, this series has described and illustrated the first four steps of the five-step evidence-based practice (EBP) process that was originally designed and taught by the medical epidemiologists of McMaster University (Hamilton, Ontario, Canada) and the National Health Service Centre for Evidence-Based Medicine (University of Oxford, Oxford, England). This article in the series first briefly considers the fifth step (evaluate). A more detailed consideration of caveats, common questions, and challenges relevant to EBP in radiology then follows. These are issues that merit some thought by those beginning or continuing work in EBP.