Abstract
Introduction:
Isolated Whipple disease of the central nervous system is a rare occurrence. Migratory arthralgias and gastrointestinal problems, including malabsorption, abdominal pain, diarrhea, and weight loss, are common presenting symptoms.
Discussion:
For those patients with systemic signs and symptoms of Whipple disease, 6% to 43% will have clinically manifested CNS involvement that may include alterations in personality, ataxia, and dementia. We report our experience with a patient, who was successfully treated for Whipple disease 12 years prior to presentation and had a magnetic resonance image of the brain that revealed two solitary lesions resembling a tumor upon presentation.
MeSH terms
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Anti-Infective Agents / therapeutic use
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Brain Neoplasms / diagnosis
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Chronic Disease / therapy
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Consciousness Disorders / etiology
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Diagnosis, Differential
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Diagnostic Errors / prevention & control*
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Encephalitis / microbiology*
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Encephalitis / pathology*
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Encephalitis / surgery
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Headache / etiology
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Humans
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Hypothalamus / microbiology
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Hypothalamus / pathology
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Neurosurgical Procedures
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Temporal Lobe / microbiology*
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Temporal Lobe / pathology*
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Temporal Lobe / surgery
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Treatment Outcome
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Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
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Tropheryma / physiology
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Whipple Disease / pathology*
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Whipple Disease / physiopathology
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Whipple Disease / surgery
Substances
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Anti-Infective Agents
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Trimethoprim, Sulfamethoxazole Drug Combination