Desmoid tumors are fibrous neoplasms that are infiltrative and locally aggressive. Although they are histologically benign with negligible metastatic potential, recurrence after surgical resection is common. Pharmacotherapy and radiation treatment have been utilized when surgery has been considered unsuitable. Since April 2003, we have used radiofrequency ablation to treat five desmoid tumors in four patients. Complications were seen in two patients; one patient had cellulitis and another had soft tissue necrosis. Clinical follow-up was available for all four patients and ranged from 4-68 months (mean 30 months). No recurrences were detected.