Optical coherence tomography (OCT) in optic neuritis and multiple sclerosis

Rev Neurol (Paris). 2010 Dec;166(12):978-86. doi: 10.1016/j.neurol.2010.03.024. Epub 2010 Jun 1.

Abstract

Optical coherence tomography (OCT) is a non-invasive imaging technique routinely used in ophthalmology to visualize and quantify the layers of the retina. It also provides information on optic nerve head topography, peripapillary retinal nerve fiber layer thickness, and macular volume, which correlate with axonal loss. These measurements are of particular interest in optic neuropathies and in multiple sclerosis, and OCT parameters are now used as endpoints in neurologic clinical trials.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Axons / pathology
  • Humans
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / drug therapy
  • Multiple Sclerosis / pathology
  • Nervous System Diseases / diagnosis
  • Nervous System Diseases / pathology
  • Neuromyelitis Optica / diagnosis
  • Neuromyelitis Optica / pathology
  • Optic Neuritis / diagnosis*
  • Optic Neuritis / drug therapy
  • Optic Neuritis / pathology
  • Retinal Neurons / pathology
  • Tomography, Optical Coherence*
  • Treatment Outcome