Purpose: To quantitatively evaluate the kinetic parameter estimation for head and neck (HN) dynamic contrast-enhanced (DCE) MRI with dual-flip-angle (DFA) T1 mapping.
Materials and methods: Clinical DCE-MRI datasets of 23 patients with HN tumors were included in this study. T1 maps were generated based on multiple-flip-angle (MFA) method and different DFA combinations. Tofts model parameter maps of k(ep), K(trans) and v(p) based on MFA and DFAs were calculated and compared. Fitted parameter by MFA and DFAs were quantitatively evaluated in primary tumor, salivary gland and muscle.
Results: T1 mapping deviations by DFAs produced remarkable kinetic parameter estimation deviations in head and neck tissues. In particular, the DFA of [2º, 7º] overestimated, while [7º, 12º] and [7º, 15º] underestimated K(trans) and v(p), significantly (P<0.01). [2º, 15º] achieved the smallest but still statistically significant overestimation for K(trans) and v(p) in primary tumors, 32.1% and 16.2% respectively. k(ep) fitting results by DFAs were relatively close to the MFA reference compared to K(trans) and v(p).
Conclusions: T1 deviations induced by DFA could result in significant errors in kinetic parameter estimation, particularly K(trans) and v(p), through Tofts model fitting. MFA method should be more reliable and robust for accurate quantitative pharmacokinetic analysis in head and neck.
Keywords: DCE-MRI; T1 mapping; Tofts model; dual-flip-angle method; head and neck.