Treatment of blister-like aneurysms with the pipeline embolization device

Neurosurgery. 2014 May;74(5):527-32; discussion 532. doi: 10.1227/NEU.0000000000000309.

Abstract

Background: Endovascular vessel reconstruction with the pipeline embolization device (PED) has become common practice. Data on the safety and efficacy of the PED in blister-like aneurysms (BLAs) are limited.

Objective: To retrospectively present our experience with use of the PED in BLAs.

Methods: A total of 8 patients harboring 8 BLAs were treated with the PED at our institution between November 2011 and April 2013.

Results: Aneurysm size was 2.5 mm on average. Five patients had sustained a subarachnoid hemorrhage (SAH), 1 patient presented with sentinel headaches, and in 2 patients the aneurysm was incidentally discovered. Seven aneurysms arose from the ICA and 1 from the basilar artery. Placement of the PED was successful in all 8 patients. There were no procedural or perioperative complications in any of the patients. At the latest follow-up, all 8 patients achieved a favorable outcome (mRS 0-2). Angiographic follow-up was available for 6 patients at a mean time point of 3.9 months. Follow-up angiography showed 100% aneurysm occlusion in 5 patients and marked decrease in aneurysm size in 1 patient.

Conclusion: The findings of this study suggest that the PED may be a safe and effective treatment for BLAs. Given the limitations of other treatment modalities and the challenging nature of BLAs, flow diversion may be a valuable option for these lesions.

Publication types

  • Case Reports
  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aneurysm, Ruptured / therapy
  • Angioplasty / instrumentation
  • Angioplasty / methods
  • Aspirin / administration & dosage
  • Basilar Artery / diagnostic imaging
  • Carotid Artery Diseases / diagnosis
  • Carotid Artery Diseases / therapy*
  • Carotid Artery, Internal / diagnostic imaging
  • Cerebral Angiography / methods
  • Clopidogrel
  • Drug Therapy, Combination
  • Embolization, Therapeutic / instrumentation*
  • Female
  • Follow-Up Studies
  • Heparin / administration & dosage
  • Humans
  • Intracranial Aneurysm / diagnosis
  • Intracranial Aneurysm / therapy*
  • Magnetic Resonance Angiography
  • Male
  • Middle Aged
  • Platelet Aggregation Inhibitors / administration & dosage
  • Premedication
  • Retrospective Studies
  • Stents
  • Ticlopidine / administration & dosage
  • Ticlopidine / analogs & derivatives
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Platelet Aggregation Inhibitors
  • Heparin
  • Clopidogrel
  • Ticlopidine
  • Aspirin