Evaluation of the antiangiogenic effects of octreotide on growth hormone-producing pituitary adenoma using arterial spin-labeling perfusion imaging

Naoto Sakai; Shuhei Yamashita; Yasuo Takehara; Harumi Sakahara; Satoshi Baba; Yutaka Oki; Goro Takahashi; Shinichiro Koizumi; Tetsuro Sameshima; Hiroki Namba

doi:10.2463/mrms.2014-0026

Evaluation of the antiangiogenic effects of octreotide on growth hormone-producing pituitary adenoma using arterial spin-labeling perfusion imaging

Magn Reson Med Sci. 2015;14(1):73-6. doi: 10.2463/mrms.2014-0026. Epub 2014 Oct 27.

Authors

Naoto Sakai¹, Shuhei Yamashita, Yasuo Takehara, Harumi Sakahara, Satoshi Baba, Yutaka Oki, Goro Takahashi, Shinichiro Koizumi, Tetsuro Sameshima, Hiroki Namba

Affiliation

¹ Department of Neurosurgery, Hamamatsu University School of Medicine.

PMID: 25345412
DOI: 10.2463/mrms.2014-0026

Abstract

Decreased absolute tumor blood flow (TBF) measured by arterial spin labeling perfusion imaging (ASL-PI) on 3-tesla magnetic resonance imaging demonstrated the reduced size and growth hormone (GH) secretion of a large GH-producing pituitary adenoma in a 32-year-old man in response to octreotide therapy. The study shows the usefulness of ASL-PI in providing a biomarker of the antiangiogenic effect of octreotide.

Publication types

Case Reports

MeSH terms

Adult
Angiogenesis Inhibitors / pharmacology*
Antineoplastic Agents, Hormonal / pharmacology*
Human Growth Hormone / metabolism
Humans
Magnetic Resonance Imaging*
Male
Octreotide / pharmacology*
Pituitary Neoplasms / blood supply*
Pituitary Neoplasms / drug therapy*
Pituitary Neoplasms / metabolism
Reproducibility of Results
Spin Labels

Substances

Angiogenesis Inhibitors
Antineoplastic Agents, Hormonal
Spin Labels
Human Growth Hormone
Octreotide