Purpose: To determine if dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) parameters such as permeability surface area (PS) and blood volume (BV) allow differentiating between new head and neck (HN) cancer, recurrent HN cancer, and post-treatment benign changes.
Method: A total of 35 patients with newly diagnosed, recurrent, and benign post-treatment benign changes underwent DCE-MRI. PS and BV were calculated.
Results: PS values of the lesion were 2.3×10(4)±5.8×10(4) for the newly diagnosed cancer group, 3.3×10(4)±1.7×10(4) for the recurrent cancer group, and 4.8×10(4)±8.1×10(4) for the post-treatment benign change group (P=.031).
Conclusion: Post-treatment benign changes in the HN region had significantly high permeability property than newly diagnosed or previously treated recurrent tumor.
Keywords: Dynamic contrast-enhanced MRI; Head and neck cancer; Permeability surface area product.
Copyright © 2015. Published by Elsevier Inc.