Infantile hemangiomas and structural anomalies: PHACE and LUMBAR syndrome

Semin Cutan Med Surg. 2016 Sep;35(3):117-23. doi: 10.12788/j.sder.2016.047.

Abstract

In a subset of patients, infantile hemangiomas may be associated with structural anomalies. Structural anomalies may affect the upper body (PHACE Syndrome) or the lower body (LUMBAR Syndrome). Since their initial descriptions, improved understanding of these two syndromes has lead to recognition of a broader phenotypic spectrum than initially recognized. This paper aims to provide an updated review of the presentation, associated anomalies, and management of PHACE and LUMBAR syndromes, two well-characterized syndromes associated with IH.

Keywords: LUMBAR Syndrome; PHACE Syndrome; infantile hemangioma; structural anomalies.

Publication types

  • Review

MeSH terms

  • Abnormalities, Multiple / diagnosis*
  • Abnormalities, Multiple / pathology
  • Abnormalities, Multiple / therapy*
  • Facial Neoplasms / complications
  • Facial Neoplasms / diagnosis*
  • Facial Neoplasms / pathology
  • Facial Neoplasms / therapy*
  • Hemangioma / complications
  • Hemangioma / diagnosis*
  • Hemangioma / pathology
  • Hemangioma / therapy*
  • Humans
  • Infant
  • Skin Neoplasms / complications
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / pathology
  • Skin Neoplasms / therapy*
  • Syndrome