Stroke risk in patients with carotid stenosis

Lancet. 1987 Apr 18;1(8538):888-90. doi: 10.1016/s0140-6736(87)92861-3.

Abstract

In 242 neurologically symptomless patients with at least one non-occlusive carotid stenosis on ultrasonography (continuous wave doppler and echotomography-B mode imaging) 171 carotids showed 0-50% stenosis, 150 showed 50-75% stenosis, and 78 showed more than 75% stenosis. The mean follow-up was 29.4 months, with stroke and death as end points. Of the 56 deaths 2 were causally linked to a stroke (crude annual mortality index 9.57%). Of the 10 strokes 7 were judged to be infarctions in carotid territory. 7 out of 20 patients with transient ischaemic attacks (TIA) had ischaemic symptoms definitely related to carotid territory. The crude annual indices of specific stroke or TIA were 0.45% for nonstenotic carotid, 0.23% for 0-50% stenosis, 2.48% for 50-75% stenosis, and 1.71% for 75-99% stenosis. Stenoses of greater than 50% were associated with more ischaemic events than were lesser degrees of narrowing (p less than 0.01).

MeSH terms

  • Aged
  • Carotid Artery Diseases / complications*
  • Cerebrovascular Disorders / epidemiology
  • Cerebrovascular Disorders / etiology*
  • Cerebrovascular Disorders / mortality
  • Constriction, Pathologic
  • Female
  • Follow-Up Studies
  • Humans
  • Ischemic Attack, Transient / epidemiology
  • Ischemic Attack, Transient / etiology
  • Male
  • Middle Aged
  • Risk