Case Report of Rarely Described Polymorphous Low-Grade Neuroepithelial Tumor of the Young and Comparison with Oligodendroglioma

World Neurosurg. 2019 Jul:127:47-51. doi: 10.1016/j.wneu.2019.03.181. Epub 2019 Mar 26.

Abstract

Background: Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a central nervous system tumor that shares many qualities with oligodendroglioma but is rarely and only very recently described as a distinct entity in the literature.

Case description: A previously healthy, 19-year-old man presented with new onset of seizures. Imaging showed an intracranial mass, which was treated with surgical removal. Preoperative and postoperative magnetic resonance imaging, histopathologic examination, genetic testing, and immunohistochemical staining all supported a diagnosis of PLNTY.

Conclusions: Diagnostic investigation of PLNTY shows many similarities with oligodendroglioma, and thus these entities can be mistaken for one another. Certain studies are needed to distinguish PLNTY and other dysembryoplastic neuroepithelial tumors, such as oligodendroglioma.

Keywords: Dysembryoplastic; Neoplasm; Neurosurgery; Oligodendroglioma; PLNTY; Polymorphous low-grade neuroepithelial tumor of the young; Seizure.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain / diagnostic imaging
  • Brain / pathology
  • Brain Neoplasms / complications
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / genetics
  • Brain Neoplasms / pathology
  • Diagnosis, Differential
  • Humans
  • Male
  • Neoplasms, Neuroepithelial / complications
  • Neoplasms, Neuroepithelial / diagnosis*
  • Neoplasms, Neuroepithelial / genetics
  • Neoplasms, Neuroepithelial / pathology
  • Oligodendroglioma / complications
  • Oligodendroglioma / diagnosis*
  • Oligodendroglioma / genetics
  • Oligodendroglioma / pathology
  • Young Adult