Abstract
Two series of derivatives of ethyl ester of 4-methyl-1H-tetrahydro-1,5-benzodiazepine-2-carboxylic acid (1) have been synthesized. The acetyl derivative (2) of ester 1 in preliminary pharmacological screening showed analgesic activity in the "writhing" test and the benzoyl derivative (5) exhibited antianxiety properties in the four plate test, while N,N-disubstituted aminoacetyl derivatives of 1 showed analgesic and anticonvulsant activity (10).
MeSH terms
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Analgesics
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Animals
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Anticonvulsants
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Apomorphine / pharmacology
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Behavior, Animal / drug effects*
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Benzodiazepines / chemical synthesis*
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Benzodiazepines / pharmacology
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Benzodiazepines / toxicity
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Chemical Phenomena
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Chemistry
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Female
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Lethal Dose 50
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Male
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Mice
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Rats
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Reserpine / antagonists & inhibitors
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Serotonin Antagonists
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Stereotyped Behavior / drug effects
Substances
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Analgesics
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Anticonvulsants
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Serotonin Antagonists
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Benzodiazepines
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Reserpine
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Apomorphine