The pediatric supratentorial MYCN-amplified high-grade gliomas methylation class presents the same radiological, histopathological and molecular features as their pontine counterparts

Affiliations

• ¹ Department of Neuropathology, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, 75014, Paris, France. a.tauziede-espariat@ghu-paris.fr.
• ² U981, Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris-Saclay, 94805, Villejuif, France.
• ³ Univ. Evry, Université Paris-Saclay, 91000, Evry, France.
• ⁴ Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, 94805, Villejuif, France.
• ⁵ Department of Pediatric Neurosurgery, Necker Hospital, APHP, Université Paris Descartes, Sorbonne Paris Cite, 75015, Paris, France.
• ⁶ Department of Neurosurgery, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, 75014, Paris, France.
• ⁷ Department of Biochemistry and Oncogenetic, Paul Brousse Hospital, 94804, Villejuif, France.
• ⁸ Department of Neuropathology, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, 75014, Paris, France.
• ⁹ Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique, Institut Curie, Paris, France.
• ¹⁰ INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.
• ¹¹ SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
• ¹² Paediatric Radiology Department, Hôpital Necker Enfants Malades, AP-HP, University de Paris, INSERM U1163, Institut Imagine, Paris, France.