Abstract
Systemic injection of pilocarpine (380 mg/kg) results in the development of motor limbic seizures in rats. Olfactory bulbectomy performed 7 days prior to pilocarpine administration has a strong protective effect against the seizures. Neuropathological changes which normally occur in this seizure model do not develop in the brains of bulbectomized animals.
MeSH terms
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Animals
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Behavior, Animal / drug effects
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Hippocampus / pathology
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Injections, Intraperitoneal
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Limbic System / drug effects
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Limbic System / physiopathology*
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Male
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Motor Neurons / drug effects
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Motor Neurons / physiopathology
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Olfactory Bulb / physiopathology*
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Olfactory Bulb / surgery
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Pilocarpine*
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Rats
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Rats, Inbred Strains
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Seizures / chemically induced*
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Seizures / pathology
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Seizures / physiopathology