Abstract
Five of 64 recipients of HLA-identical sibling marrow allografts who were given cyclosporin (CSP) to minimize graft-versus-host disease posttransplant had a serious neurological illness thought to be due to CSP. Characteristic clinical features included a motor spinal cord syndrome, a cerebellar-like syndrome, and mental confusion. All five recovered when the CSP dose was reduced or the drug was stopped.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Kidney Injury / chemically induced
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Adult
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Ataxia / chemically induced
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Bone Marrow Transplantation*
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Central Nervous System Diseases / chemically induced*
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Confusion / chemically induced
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Cyclosporins / therapeutic use
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Cyclosporins / toxicity*
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Female
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Graft vs Host Disease / prevention & control
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Humans
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Leukemia, Myeloid / therapy
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Male
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Memory Disorders / chemically induced
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Middle Aged
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Pyramidal Tracts / drug effects
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Tremor / chemically induced