A 48-year-old woman was examined who had a limited form of Wegener's granulomatosis with neurologic manifestations. Despite the relative frequency of neurologic manifestations, we found only two other cases in the literature in which intracerebral granulomas were involved. Moreover, mammary manifestations with necrotizing granulomas developed in this case. Glucocorticoid treatment was effective because the case showed both brain and mammary involvement. This case was uncommon in that the intracerebral and mammary granulomas developed in an area remote from that usually affected by Wegener's granulomatosis.