To reduce radiation exposure to patients and staff during neurointerventional procedures, region-of-interest (ROI) techniques were used with fluoroscopy, road mapping, and digital subtraction angiography in 19 patients. ROI filters, made of multiple layers of gadolinium, were attached to the collimators. Patient skin exposure was reduced by a factor of 3.3-10.0 across 85% of the field of view, and exposures were reduced to below thresholds for skin effects.