Nontoxic embolic liquids for treatment of arteriovenous malformations

J Biomed Mater Res. 1997 Summer;38(2):79-86. doi: 10.1002/(sici)1097-4636(199722)38:2<79::aid-jbm1>3.0.co;2-d.

Abstract

Interventional radiology is becoming one of the standard treatments of arteriovenous malformation (AVM). Cyanoacrylate derivatives and polymer solutions are widely used to occlude the AVM nidus by their injection through a catheter, but they are far from satisfactory embolic liquids. For instance, cyanoacrylate derivatives sometimes glue the catheter to the artery, resulting in serious complications; in addition, the organic solvents used to dissolve polymers cause damage to the surrounding brain tissue of the AVM. Therefore, we attempted to develop embolic liquids by dissolving poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) in Iopamiron with an addition of a small amount of ethyl alcohol. This new embolic liquid is not cytotoxic and is easily injected into the AVM through a thin, long catheter to effectively occlude the AVM.

MeSH terms

  • Animals
  • Arteriovenous Malformations / therapy*
  • Biocompatible Materials* / toxicity
  • Brain / pathology
  • Cell Line
  • Cyanoacrylates
  • Embolization, Therapeutic*
  • Humans
  • Intracranial Arteriovenous Malformations / diagnostic imaging
  • Intracranial Arteriovenous Malformations / therapy*
  • Methylmethacrylates / chemical synthesis
  • Methylmethacrylates / chemistry*
  • Methylmethacrylates / toxicity
  • Mice
  • Polyhydroxyethyl Methacrylate / chemical synthesis
  • Polyhydroxyethyl Methacrylate / chemistry*
  • Polyhydroxyethyl Methacrylate / toxicity
  • Rabbits
  • Radiography

Substances

  • Biocompatible Materials
  • Cyanoacrylates
  • Methylmethacrylates
  • Polyhydroxyethyl Methacrylate
  • HTR composite