Local differences in chromatin organisation may profoundly affect the activity of eukaryotic
genomes. Regulation at the level of DNA packaging requires the targeting of structural …

The retinoblastoma protein (Rb) silences specific genes that are active in the S phase of the
cell cycle and which are regulated by E2F transcription factors 1 . Rb binds to the activation …

Inactivation of the retinoblastoma tumour suppressor protein (pRb) is a hallmark of most
human cancers. Accordingly, pRb is serving as a paradigm in our quest to understand tumour …

Gene transcription is tightly regulated at different levels to ensure that the transcriptome of
the cell is appropriate for developmental stage and cell type. The chromatin state in which a …

Insulin resistance correlates with intramyocellular lipid content (IMCL) and plasma free fatty
acids (FFAs) and was recently linked to mitochondrial dysfunction. We examined the …

E7 is the main transforming protein of human papilloma virus type 16 (HPV16) which is
implicated in the formation of cervical cancer. The transforming activity of E7 has been attributed …

The DNA methyltransferase Dnmt1 is responsible for cytosine methylation in mammals and
has a role in gene silencing 1, 2, 3, 4. DNA methylation represses genes partly by …

During the G 1 phase of the cell cycle, an E2F–RB complex represses transcription, via the
recruitment of histone deacetylase activity. Phosphorylation of RB at the G 1/S boundary …

The retinoblastoma tumor suppressor protein (pRb) regulates gene transcription by binding
E2F transcription factors. pRb can recruit several repressor complexes to E2F bound …

The totipotential stem cells of the pregastrulation mouse embryo which give rise to all embryonic
somatic tissues and germ cells express Oct-4. The expression is downregulated during …