APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
…, AP Sagare, G Barisano, MD Sweeney, A Chakhoyan… - Nature, 2020 - nature.com
Vascular contributions to dementia and Alzheimer’s disease are increasingly recognized 1 ,
2 , 3 , 4 , 5 – 6 . Recent studies have suggested that breakdown of the blood–brain barrier (…
2 , 3 , 4 , 5 – 6 . Recent studies have suggested that breakdown of the blood–brain barrier (…
Diffusion MRI phenotypes predict overall survival benefit from anti-VEGF monotherapy in recurrent glioblastoma: converging evidence from phase II trials
…, GM Schwab, C Hessel, RJ Harris, A Chakhoyan… - Clinical Cancer …, 2017 - AACR
Purpose: Anti-VEGF therapies remain controversial in the treatment of recurrent glioblastoma
(GBM). In the current study, we demonstrate that recurrent GBM patients with a specific …
(GBM). In the current study, we demonstrate that recurrent GBM patients with a specific …
Simultaneous p H‐sensitive and oxygen‐sensitive MRI of human gliomas at 3 T using multi‐echo amine proton chemical exchange saturation transfer spin‐and …
RJ Harris, J Yao, A Chakhoyan… - Magnetic resonance …, 2018 - Wiley Online Library
Simultaneous pH‐sensitive and oxygen‐sensitive MRI of human gliomas at 3 T using multi‐echo
amine proton chemical exchange saturation transfer spin‐and‐gradient echo echo‐…
amine proton chemical exchange saturation transfer spin‐and‐gradient echo echo‐…
Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH-and oxygen-sensitive molecular MRI
Background Isocitrate dehydrogenase 1 (IDH1) mutant gliomas are thought to have distinct
metabolic characteristics, including a blunted response to hypoxia and lower glycolytic flux. …
metabolic characteristics, including a blunted response to hypoxia and lower glycolytic flux. …
[HTML][HTML] Validation of vessel size imaging (VSI) in high-grade human gliomas using magnetic resonance imaging, image-guided biopsies, and quantitative …
To evaluate the association between a vessel size index (VSI MRI ) derived from dynamic
susceptibility contrast (DSC) perfusion imaging using a custom spin-and-gradient echo …
susceptibility contrast (DSC) perfusion imaging using a custom spin-and-gradient echo …
[HTML][HTML] Imaging modalities to assess oxygen status in glioblastoma
A Corroyer-Dulmont, A Chakhoyan, S Collet… - Frontiers in …, 2015 - frontiersin.org
Hypoxia, the result of an inadequacy between a disorganized and functionally impaired
vasculature and the metabolic demand of tumor cells, is a feature of glioblastoma. Hypoxia …
vasculature and the metabolic demand of tumor cells, is a feature of glioblastoma. Hypoxia …
[HTML][HTML] pH-weighted molecular MRI in human traumatic brain injury (TBI) using amine proton chemical exchange saturation transfer echoplanar imaging (CEST EPI)
Cerebral acidosis is a consequence of secondary injury mechanisms following traumatic
brain injury (TBI), including excitotoxicity and ischemia, with potentially significant clinical …
brain injury (TBI), including excitotoxicity and ischemia, with potentially significant clinical …
Volumetric response quantified using T1 subtraction predicts long-term survival benefit from cabozantinib monotherapy in recurrent glioblastoma
…, DC Woodworth, K Leu, A Chakhoyan… - Neuro …, 2018 - academic.oup.com
Background To overcome challenges with traditional response assessment in anti-angiogenic
agents, the current study uses T1 subtraction maps to quantify volumetric radiographic …
agents, the current study uses T1 subtraction maps to quantify volumetric radiographic …
18F-FDOPA PET and MRI characteristics correlate with degree of malignancy and predict survival in treatment-naïve gliomas: a cross-sectional study
CB Patel, E Fazzari, A Chakhoyan, J Yao… - Journal of neuro …, 2018 - Springer
Introduction To report the potential value of pre-operative 18 F-FDOPA PET and anatomic
MRI in diagnosis and prognosis of glioma patients. Methods Forty-five patients with a …
MRI in diagnosis and prognosis of glioma patients. Methods Forty-five patients with a …
Mono-exponential, diffusion kurtosis and stretched exponential diffusion MR imaging response to chemoradiation in newly diagnosed glioblastoma
A Chakhoyan, DC Woodworth, RJ Harris, A Lai… - Journal of neuro …, 2018 - Springer
Purpose To quantify changes and prognostic value of diffusion MRI measurements obtained
using mono-exponential, diffusion kurtosis imaging (DKI) and stretched exponential (SE) …
using mono-exponential, diffusion kurtosis imaging (DKI) and stretched exponential (SE) …
